Glecaprevir Pibrentasvir

Glecaprevir Pibrentasvir Brand Name– Mavyret

What is Glecaprevir Pibrentasvir

Glecaprevir pibrentasvir is an oral fixed-dose combination of glecaprevir, a hepatitis C virus (HCV) NS3/4A protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor.

The drug is approved to treat chronic HCV genotypes 1, 2, 3, 4, 5, and 6 infections in adults and pediatric patients (12 years and older or weighing at least 45 kg) who are without cirrhosis or have compensated cirrhosis (Child-Pugh A).

For all HCV genotypes, the drug may be given to treatment-naive patients and to patients who previously received an antiviral regimen containing an interferon, ribavirin, and/or sofosbuvir.

The drug is also indicated to treat patients with HCV genotype 1 infection who were previously treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both.

For treatment-naive patients, the duration of therapy is 8 weeks; however, the duration in treatment-experienced patients ranges from 8 to 16 weeks based on genotype and previous treatment history.

Glecaprevir pibrentasvir is contraindicated for use in patients with moderate to severe hepatic impairment (Child-Pugh B or C) and in those with any history of prior hepatic decompensation.

Indications

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  1. angioedema
  2. asthenia
  3. diarrhea
  4. fatigue
  5. headache
  6. hepatic decompensation
  7. hepatic failure
  8. hepatitis B exacerbation
  9. hyperbilirubinemia
  10. jaundice
  11. nausea
  12. pruritus

Monitoring Parameters

  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA

Contraindications

  • alcoholism
  • anticoagulant therapy
  • ascites
  • breast-feeding
  • diabetes mellitus
  • hepatic decompensation
  • hepatic disease
  • hepatic encephalopathy
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • hepatocellular cancer
  • hyperglycemia
  • hypoglycemia
  • jaundice
  • pregnancy

Interactions

  • Acalabrutinib
  • Acarbose
  • Acetohexamide
  • Afatinib
  • Albiglutide
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpelisib
  • Amiodarone
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  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Antidiabetic Agents
  • Apalutamide
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
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  • grapefruit juice
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