Gentamicin

Gentamicin Brand Names

Garamycin | Genoptic | Genoptic SOP | Gentacidin | Gentafair | Gentak | Gentasol | Ocu-Mycin

What is Gentamicin

Gentamicin is an aminoglycoside antibiotic obtained from cultures of Micromonospora purpurea.

Gentamicin is most active against aerobic gram-negative rods, but it is also used in combination with other antibiotics to treat Staphylococcus aureus and certain species of streptococcus.

Gentamicin and some other aminoglycosides are used in combination with a penicillin for the treatment of endocarditis.

Gentamicin is active against certain Mycobacterium species but is not active against any anaerobic bacteria.

Gentamicin was approved by the FDA in 1966.

Indications

  1. Acinetobacter sp.
  2. Aeromonas sp.
  3. appendicitis
  4. Bacillus anthracis
  5. bacteremia
  6. bacterial conjunctivitis
  7. Bartonella quintana
  8. bartonellosis
  9. blepharitis
  10. blepharoconjunctivitis
  11. bone and joint infections
  12. Brucella sp.
  13. burn wound infection
  14. cellulitis
  15. Citrobacter sp.
  16. community-acquired pneumonia
  17. corneal ulcer
  18. cystic fibrosis
  19. dacryocystitis
  20. dermatitis
  21. eczema
  22. endocarditis
  23. Enterobacter sp.
  24. Enterococcus sp.
  25. enterocolitis
  26. Escherichia coli
  27. febrile neutropenia
  28. folliculitis
  29. Francisella tularensis
  30. furunculosis
  31. gonorrhea
  32. granuloma inguinale
  33. Haemophilus influenzae (beta-lactamase negative)
  34. Haemophilus influenzae (beta-lactamase positive)
  35. impetigo
  36. infectious arthritis
  37. intraabdominal infections
  38. keratitis
  39. keratoconjunctivitis
  40. Klebsiella aerogenes
  41. Klebsiella pneumoniae
  42. Klebsiella sp.
  43. lower respiratory tract infections
  44. meibomianitis
  45. meningitis
  46. Morganella sp.
  47. Neisseria gonorrhoeae
  48. nosocomial pneumonia
  49. osteomyelitis
  50. pelvic inflammatory disease (PID)
  51. peritonitis
  52. plague
  53. pneumonia
  54. Proteus sp.
  55. Proteus vulgaris
  56. Providencia sp.
  57. Pseudomonas aeruginosa
  58. psoriasis
  59. pyelonephritis
  60. pyoderma gangrenosum
  61. Salmonella sp.
  62. seborrheic dermatitis
  63. sepsis
  64. Serratia marcescens
  65. Serratia sp.
  66. Shigella sp.
  67. skin and skin structure infections
  68. Staphylococcus aureus (MSSA)
  69. Staphylococcus epidermidis
  70. Staphylococcus sp.
  71. Streptococcus pneumoniae
  72. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  73. surgical infection prophylaxis
  74. tubo-ovarian abscess
  75. tularemia
  76. urinary tract infection (UTI)
  77. ventriculitis
  78. Yersinia pestis

Side Effects

  1. agranulocytosis
  2. alopecia
  3. anaphylactoid reactions
  4. anemia
  5. arthralgia
  6. azotemia
  7. confusion
  8. conjunctival hyperemia
  9. conjunctivitis
  10. cylindruria
  11. depression
  12. dizziness
  13. elevated hepatic enzymes
  14. encephalopathy
  15. eosinophilia
  16. erythema
  17. fever
  18. hallucinations
  19. headache
  20. hearing loss
  21. hepatomegaly
  22. hyperbilirubinemia
  23. hypersalivation
  24. hypertension
  25. hypocalcemia
  26. hypokalemia
  27. hypomagnesemia
  28. hyponatremia
  29. hypotension
  30. impaired wound healing
  31. increased intracranial pressure
  32. injection site reaction
  33. laryngeal edema
  34. lethargy
  35. leukopenia
  36. myasthenia
  37. nausea
  38. nephrotoxicity
  39. neurotoxicity
  40. ocular irritation
  41. oliguria
  42. ototoxicity
  43. paresthesias
  44. peripheral neuropathy
  45. phlebitis
  46. photosensitivity
  47. proteinuria
  48. pruritus
  49. pseudotumor cerebri
  50. pulmonary fibrosis
  51. purpura
  52. pyuria
  53. rash
  54. renal tubular acidosis (RTA)
  55. respiratory depression
  56. skin irritation
  57. splenomegaly
  58. stomatitis
  59. tetany
  60. thrombocytopenia
  61. tinnitus
  62. urticaria
  63. vertigo
  64. vitamin B12 deficiency
  65. vitamin B6 deficiency
  66. vomiting
  67. weakness
  68. weight loss

Monitoring Parameters

  • audiometry
  • serum aminoglycoside concentrations
  • serum creatinine/BUN

Contraindications

  • aminoglycoside hypersensitivity
  • antimicrobial resistance
  • botulism
  • breast-feeding
  • colitis
  • corneal abrasion
  • dehydration
  • diarrhea
  • electrolyte imbalance
  • fungal infection
  • geriatric
  • GI disease
  • hearing impairment
  • inflammatory bowel disease
  • myasthenia gravis
  • neonates
  • nephrotoxicity
  • neuromuscular disease
  • neurotoxicity
  • ototoxicity
  • parkinsonism
  • pregnancy
  • premature neonates
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory insufficiency
  • sexually transmitted disease
  • sulfite hypersensitivity
  • tinnitus
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Diphenhydramine
  • Acyclovir
  • Adefovir
  • Aldesleukin, IL-2
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Aprotinin
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Bacitracin
  • Beclomethasone
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betamethasone
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bleomycin
  • Botulinum Toxins
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Capreomycin
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carboplatin
  • Cefepime
  • Cefotaxime
  • Cefotetan
  • Cefoxitin
  • Cefprozil
  • Ceftazidime
  • Ceftazidime; Avibactam
  • Ceftizoxime
  • Cefuroxime
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Cidofovir
  • Cisatracurium
  • Cisplatin
  • Clofarabine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Corticosteroids
  • Cortisone
  • Cyclizine
  • Cyclosporine
  • Cytarabine, ARA-C
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deferasirox
  • Deflazacort
  • Dexamethasone
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Digoxin
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxacurium
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enflurane
  • Entecavir
  • Ethacrynic Acid
  • Etomidate
  • Fludrocortisone
  • Flunisolide
  • Fluphenazine
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Foscarnet
  • Furosemide
  • Gallium
  • Gallium Ga 68 Dotatate
  • Galsulfase
  • Ganciclovir
  • Ginger, Zingiber officinale
  • Gold
  • Halothane
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydrocortisone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibandronate
  • Ibuprofen lysine
  • Immune Globulin IV, IVIG, IGIV
  • Inotersen
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isoflurane
  • Isosulfan Blue
  • Ketamine
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lithium
  • Magnesium Salicylate
  • Mannitol
  • Meclizine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methohexital
  • Methylprednisolone
  • Mivacurium
  • Mometasone
  • Neuromuscular blockers
  • Non-Ionic Contrast Media
  • Nonsteroidal antiinflammatory drugs
  • Oral Contraceptives
  • Pamidronate
  • Pancuronium
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Polymyxin B
  • Polymyxins
  • Prednisolone
  • Prednisone
  • Promethazine
  • Propofol
  • Pyridostigmine
  • Rapacuronium
  • Rocuronium
  • Salicylates
  • Salsalate
  • Scopolamine
  • Sevoflurane
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptozocin
  • Succinylcholine
  • Sulfacetamide
  • Sulfacetamide; Sulfur
  • Surfactants
  • Tacrolimus
  • Telavancin
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thiopental
  • Thioridazine
  • Tolvaptan
  • Torsemide
  • Tretinoin, ATRA
  • Triamcinolone
  • Trifluoperazine
  • Trimethobenzamide
  • Tubocurarine
  • Urea
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Vecuronium
  • Warfarin
  • Zalcitabine, ddC
  • Zoledronic Acid