Fluorometholone Sulfacetamide Brand Name– FML S
What is Fluorometholone Sulfacetamide
Fluorometholone Sulfacetamide (FML-S Liquifilm) is combination ophthalmic suspension consisting of a synthetic fluorinated corticosteroid (structurally related to progesterone) and a synthetic sulfonamide antibiotic.
This combination product is indicated for treating steroid-responsive inflammatory ocular conditions when a superficial bacterial ocular infection with susceptible organisms is proven or suspected.
Use of sulfonamides has declined due to development of resistance, especially in Staphylococcal species.
Prolonged used of corticosteroids has been associated with increasing intraocular pressure.
The FDA approved Fluorometholone Sulfacetamide ophthalmic suspension in September 1989.
Indications
- Actinomyces sp.
- bacterial conjunctivitis
- blepharoconjunctivitis
- Chlamydia trachomatis
- corneal abrasion
- corneal ulcer
- Enterobacter sp.
- Escherichia coli
- giant papillary conjunctivitis (GPC)
- Haemophilus aegyptius
- keratitis
- Klebsiella pneumoniae
- Klebsiella sp.
- Nocardia sp.
- ocular burns
- postoperative ocular inflammation
- Proteus vulgaris
- Salmonella sp.
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- uveitis
- Viridans streptococci
Side Effects
- agranulocytosis
- aplastic anemia
- cataracts
- conjunctival hyperemia
- conjunctivitis
- corneal erosion
- hepatic necrosis
- impaired wound healing
- keratitis
- mydriasis
- ocular hypertension
- ocular irritation
- ocular pain
- ocular pruritus
- ptosis
- Stevens-Johnson syndrome
- superinfection
- toxic epidermal necrolysis
- uveitis
Monitoring Parameters
- ophthalmologic exam
Contraindications
- breast-feeding
- cataracts
- children
- contact lenses
- corticosteroid hypersensitivity
- fungal infection
- glaucoma
- herpes infection
- immunosuppression
- increased intraocular pressure
- infants
- mycobacterial infection
- ocular surgery
- pregnancy
- sulfonamide hypersensitivity
- varicella
- viral infection
Interactions
There are no drug interactions associated with Fluorometholone Sulfacetamide products.
