Ferric Citrate Brand Name– Auryxia
What is Ferric Citrate
Ferric citrate is a phosphate binder and an iron replacement product indicated for the control of serum phosphorus concentrations in adults with chronic kidney disease on dialysis and for the treatment of iron-deficiency anemia in adults with chronic kidney disease not on dialysis.
In clinical trials, ferric citrate effectively lowered serum phosphorus concentrations and increased iron stores.
The safety and efficacy of ferric citrate were comparable to that of standard therapy (i.e., sevelamer carbonate or calcium acetate).
The need for intravenous iron and erythropoietin-stimulating agents was lower in patients receiving ferric citrate compared with standard therapy.
Because use of ferric citrate may lead to excessive elevations in iron stores, the drug is contraindicated for use in patients with iron overload syndromes and iron parameters should be monitored routinely
Indications
- hyperphosphatemia
- iron-deficiency anemia
For the management of hyperphosphatemia in patients with chronic kidney disease on dialysis
Side Effects
- abdominal pain
- constipation
- cough
- diarrhea
- hyperkalemia
- nausea
- stool discoloration
- vomiting
Monitoring Parameters
- ferritin
- serum phosphate
- transferrin
Contraindications
- breast-feeding
- GI bleeding
- hemochromatosis
- inflammatory bowel disease
- pregnancy
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acetohydroxamic Acid
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisphosphonates
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Cefdinir
- Cholestyramine
- Cimetidine
- Ciprofloxacin
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Delafloxacin
- Dexlansoprazole
- Didanosine, ddI
- Dimercaprol
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Eltrombopag
- enteral feedings
- Epoetin Alfa
- Esomeprazole
- Esomeprazole; Naproxen
- Famotidine
- Famotidine; Ibuprofen
- Ferric carboxymaltose
- Ferumoxytol
- food
- Gemifloxacin
- Green Tea
- H2-blockers
- Hydrochlorothiazide, HCTZ; Methyldopa
- Ibritumomab Tiuxetan
- Iron – Injectable Only
- Iron Dextran
- Iron Sucrose, Sucroferric Oxyhydroxide
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Levodopa
- Levofloxacin
- Methoxy polyethylene glycol-epoetin beta
- Methyldopa
- Moxifloxacin
- Mycophenolate
- Nizatidine
- Norfloxacin
- Ofloxacin
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Pantoprazole
- Penicillamine
- Phosphorated Carbohydrate Solution
- Phosphorus
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Proton pump inhibitors
- Rabeprazole
- Ranitidine
- Sodium Bicarbonate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tetracyclines
- Thyroid hormones
- Trientine
- Zinc
