Fam Trastuzumab deruxtecan Brand Name– ENHERTU
What is Fam Trastuzumab deruxtecan
Fam trastuzumab deruxtecan is a HER2-targeted antibody-drug conjugate (ADC) that contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the topoisomerase I inhibitor drug, DXd (a derivative of exatecan) by a stable protease-cleavable maleimide tetrapeptide linker.
It is indicated for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting; in the clinical trial, the median number of prior cancer regimens in the locally advanced/metastatic setting was 5 (range, 2 to 17).
Cases of interstitial lung disease and pneumonitis have been reported with fam-trastuzumab deruxtecan treatment; use with caution in patients with a history of lung disease.
Do not substitute fam-trastuzumab deruxtecan for or with other trastuzumab-based products.
Indications
- breast cancer
For the treatment of breast cancer
for the treatment of unresectable or metastatic HER2-positive breast cancer in patients who have received 2 or more prior anti-HER2-based regimens in the metastatic setting
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- antibody formation
- asthenia
- asthenia
- constipation
- constipation
- cough
- diarrhea
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- fatigue
- fatigue
- GI obstruction
- headache
- heart failure
- hepatic failure
- hypokalemia
- hypokalemia
- infection
- influenza
- infusion-related reactions
- interstitial lung disease
- interstitial lung disease
- leukopenia
- leukopenia
- lymphopenia
- maculopapular rash
- migraine
- nausea
- nausea
- neutropenia
- neutropenia
- oral ulceration
- pneumonitis
- pneumonitis
- rash
- stomatitis
- stomatitis
- teratogenesis
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- xerophthalmia
- xerophthalmia
Monitoring Parameters
- CBC with differential
- ejection fraction
- pregnancy testing
Contraindications
- breast-feeding
- cardiac disease
- contraception requirements
- ensure correct formulation selection
- geriatric
- heart failure
- hepatic disease
- infertility
- interstitial lung disease
- male-mediated teratogenicity
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- reproductive risk
Interactions
There are no drug interactions associated with Fam Trastuzumab deruxtecan products.
