Ethanol

Ethanol Brand Name– Ablysinol

What is Ethanol

Ethanol or ethyl alcohol is a widely used CNS depressant. Clinically, its main use has been in the treatment of methanol or ethylene glycol poisoning.

Other uses include injection next to nerves or sympathetic ganglia to relieve long-lasting pain such as that occurring in trigeminal neuralgia or inoperable carcinoma and injection into renal arteries to ablate renal tissue such as in recipients of a renal allograft whose native kidney(s) may still be secreting renin.

Ethanol is an excellent solvent and is often used as a vehicle for medicinal preparations.

Fomepizole is an alternative agent for the treatment of ethylene glycol and methanol poisoning and is often preferred due to it’s higher potency to inhibit alcohol dehydrogenase, longer duration of action, easy administration, minimal adverse reactions, and monitoring of fomepizole blood concentrations are not necessary.

Indications

1. ethylene glycol poisoning
2. methanol poisoning

For the treatment of ethylene glycol poisoning or methanol poisoning

Side Effects

1. amnesia
2. ataxia
3. cardiomyopathy
4. cerebral degeneration
5. cirrhosis
6. coma
7. confusion
8. delirium
9. diaphoresis
10. dizziness
11. drowsiness
12. elevated hepatic enzymes
13. emotional lability
14. ethanol intoxication
15. euphoria
16. fecal incontinence
17. fetal alcohol syndrome
18. fever
19. flushing
20. gastritis
21. hallucinations
22. hepatitis
23. hyperesthesia
24. hypertension
25. impaired cognition
26. impotence (erectile dysfunction)
27. myopathy
28. nausea
29. neuritis
30. orthostatic hypotension
31. pancreatitis
32. physiological dependence
33. respiratory depression
34. seizures
35. sinus tachycardia
36. tolerance
37. tremor
38. urinary incontinence
39. vertigo
40. vomiting
41. withdrawal

Monitoring Parameters

• ECG

Contraindications

• alcoholism
• anticoagulant therapy
• breast-feeding
• CNS depression
• diabetes mellitus
• hepatic disease
• MAOI therapy
• pregnancy
• renal impairment
• seizure disorder
• surgery

Interactions

• Abacavir
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• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
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