Erythromycin

Erythromycin Brand Names

A/T/S | Akne-mycin | E.E.S. | Emcin Clear | EMGEL | E-Mycin | ERYC | Erycette | Eryderm | Erygel | Erymax | EryPed | Ery-Tab | Erythra Derm | Erythrocin | Erythrocin Lactobionate | Erythrocin Stearate | Ilosone | Ilotycin | My-E | PCE | PCE Dispertab | Romycin | Staticin | T-Stat

What is Erythromycin

Erythromycin is a macrolide antibiotic produced by Streptomyces erythraeus and was the first of several macrolide antibiotics now on the market.

Although erythromycin is active against many microbes, its clinical applications are relatively few.

Erythromycin is commonly used in the treatment of Legionnaire’s disease and Mycoplasma pneumoniae pneumonia, and as an alternative to beta-lactam antibiotics in patients who are allergic.

Erythromycin may have benefits in hypomotility conditions, such as diabetic gastroparesis, due to its actions of increased gastric motility and emptying. Erythromycin was approved by the FDA in 1952 and is available in parenteral, topical, and many oral dosage forms.

Indications

1. acne vulgaris
2. Actinomyces sp.
3. amebiasis
4. Bacillus anthracis
5. bacterial colonization eradication
6. bartonellosis
7. Bordetella pertussis
8. Borrelia burgdorferi
9. bowel preparation
10. Brucella sp.
11. burn wound infection
12. Campylobacter jejuni
13. campylobacteriosis
14. chancroid
15. chlamydia infection
16. Chlamydia sp.
17. Chlamydia trachomatis
18. chlamydial conjunctivitis
19. cholera
20. Clostridium perfringens
21. Clostridium sp.
22. community-acquired pneumonia
23. Corynebacterium diphtheriae
24. Corynebacterium minutissimum
25. Corynebacterium sp.
26. diabetic gastroparesis
27. diphtheria
28. diphtheria prophylaxis
29. Entamoeba histolytica
30. Erysipelothrix sp.
31. erythrasma
32. feeding intolerance
33. gastroparesis
34. granuloma inguinale
35. Haemophilus ducreyi
36. Haemophilus influenzae (beta-lactamase negative)
37. Haemophilus influenzae (beta-lactamase positive)
38. Helicobacter pylori
39. impetigo
40. infantile acne
41. Klebsiella granulomatis
42. Legionella pneumophila
43. Legionnaire’s disease
44. Listeria monocytogenes
45. listeriosis
46. lower respiratory tract infections
47. Lyme disease
48. lymphogranuloma venereum
49. Moraxella catarrhalis
50. Mycobacterium kansasii
51. Mycobacterium scrofulaceum
52. Mycoplasma pneumoniae
53. Neisseria gonorrhoeae
54. Neisseria meningitidis
55. Neisseria sp.
56. Nocardia asteroides
57. non-gonococcal urethritis (NGU)
58. ophthalmia neonatorum
59. ophthalmia neonatorum prophylaxis
60. ophthalmic infection
61. Pasteurella sp.
62. pelvic inflammatory disease (PID)
63. Peptococcus sp.
64. Peptostreptococcus sp.
65. pertussis (whooping cough)
66. pertussis prophylaxis
67. pharyngitis
68. pneumococcal prophylaxis
69. pneumonia
70. preterm premature rupture of membranes
71. Propionibacterium acnes
72. rheumatic fever prophylaxis
73. Rickettsia sp.
74. sickle cell disease
75. skin and skin structure infections
76. Staphylococcus aureus (MSSA)
77. Staphylococcus sp.
78. Streptococcus agalactiae (group B streptococci)
79. Streptococcus pneumoniae
80. Streptococcus pyogenes (group A beta-hemolytic streptococci)
81. Streptococcus sp.
82. syphilis
83. tetanus
84. tonsillitis
85. Treponema pallidum
86. upper respiratory tract infections
87. Ureaplasma urealyticum
88. Vibrio cholerae
89. Viridans streptococci

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. anorexia
4. cardiac arrest
5. diarrhea
6. elevated hepatic enzymes
7. erythema
8. erythema multiforme
9. hearing loss
10. hepatitis
11. injection site reaction
12. interstitial nephritis
13. Jarisch-Herxheimer reaction
14. jaundice
15. nausea
16. ocular irritation
17. pancreatitis
18. phlebitis
19. pruritus
20. pseudomembranous colitis
21. pyloric stenosis
22. QT prolongation
23. rash
24. seizures
25. skin irritation
26. Stevens-Johnson syndrome
27. superinfection
28. torsade de pointes
29. toxic epidermal necrolysis
30. urticaria
31. vomiting
32. xerosis

Monitoring Parameters

• ECG
• LFTs

Contraindications

• apheresis
• AV block
• benzyl alcohol hypersensitivity
• bradycardia
• breast-feeding
• cardiomyopathy
• celiac disease
• colitis
• diarrhea
• females
• fever
• geriatric
• GI disease
• hearing impairment
• heart failure
• hepatic disease
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• inflammatory bowel disease
• long QT syndrome
• macrolide hypersensitivity
• myasthenia gravis
• myocardial infarction
• neonates
• pheochromocytoma
• pregnancy
• pseudomembranous colitis
• QT prolongation
• rheumatoid arthritis
• seizure disorder
• sexually transmitted disease
• sickle cell disease
• sleep deprivation
• stroke
• systemic lupus erythematosus (SLE)
• ulcerative colitis
• viral infection

Interactions

• Abarelix
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• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
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• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
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• Acetaminophen; Codeine
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