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Ergoloid Mesylates Brand Names- Hydergine | Hydergine LC
What is Ergoloid Mesylates
Ergoloid mesylates contain a combination of synthetic derivatives of naturally occurring ergot alkaloids (dihydroergocornine, dihydroergocristine, and dihydroergocryptine), and are otherwise referred to as dihydrogenated ergot alkaloids.
Dihydroergotoxine mesylate, or co-dergocrine mesylate, are other synonyms for ergoloid mesylates.
Ergoloid mesylates are used orally as adjunctive therapy to treat the symptoms of age-related or idiopathic decline in mental capacity associated with dementia. The mechanism of action in improving mental capacity is unknown.
At therapeutic doses, ergoloid mesylates have few side effects and lack the vasoconstrictor properties of the natural ergot alkaloids.
Despite a favorable safety profile, the role of ergoloid mesylates in the management of dementia or Alzheimer’s disease is controversial; guidelines recommend further, well controlled trials of sufficient capacity to determine efficacy.
In 1990, a controlled study reported no differences in efficacy between ergoloid mesylates and placebo in patients with Alzheimer’s disease.
In contrast, a 1994 meta-analysis of ergoloid mesylates efficacy trials identified some improvements in Alzheimer’s dementia symptoms; however, this improvement was not statistically significant.
Ergoloid mesylates have been marketed for prescription use since 1951.
Indications
- Alzheimer’s disease
- vascular dementia
For the treatment of idiopathic decline in mental capacity or decline due to underlying dementia, such as Alzheimer’s dementia or vascular dementia
Side Effects
- anorexia
- blurred vision
- bradycardia
- dizziness
- dyspepsia
- flushing
- headache
- hypotension
- nasal congestion
- nausea
- orthostatic hypotension
- rash
- syncope
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- bradycardia
- breast-feeding
- children
- ergot alkaloid hypersensitivity
- geriatric
- hepatic disease
- hypotension
- infants
- labor
- obstetric delivery
- pregnancy
- psychosis
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Almotriptan
- Amphetamine; Dextroamphetamine Salts
- Aprepitant, Fosaprepitant
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Boceprevir
- Bromocriptine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Cabergoline
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloroprocaine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Citalopram
- Conivaptan
- Danazol
- Delavirdine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dobutamine
- Duloxetine
- Elbasvir; Grazoprevir
- Eletriptan
- Escitalopram
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Frovatriptan
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Imatinib
- Isoproterenol
- Itraconazole
- Ketoconazole
- Letermovir
- Levomilnacipran
- Lidocaine; Prilocaine
- Linezolid
- Lisdexamfetamine
- Loratadine; Pseudoephedrine
- Lorcaserin
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Miconazole
- Milnacipran
- Mirtazapine
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nicardipine
- Nicotine
- Nilotinib
- Nitrates
- Nitroprusside
- Paroxetine
- Phentermine
- Phentermine; Topiramate
- Posaconazole
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Protease inhibitors
- Pseudoephedrine
- Quinine
- Ranolazine
- Rizatriptan
- Rufinamide
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Sumatriptan
- Tedizolid
- Telaprevir
- Telithromycin
- tobacco
- Trandolapril; Verapamil
- Vasopressors
- Venlafaxine
- Verapamil
- Vilazodone
- Voriconazole
- Vortioxetine
- Zileuton
- Zolmitriptan