Enalapril Hydrochlorothiazide HCTZ

Enalapril Hydrochlorothiazide HCTZ Brand Name– Vaseretic

What is Enalapril Hydrochlorothiazide HCTZ

Enalapril Hydrochlorothiazide HCTZ are combined in an oral formulation for the treatment of hypertension.

Enalapril is an angiotensin converting enzyme inhibitor similar to captopril and lisinopril. Hydrochlorothiazide is a commonly used thiazide diuretic.

The extent of blood pressure reduction with the combination of enalapril and hydrochlorothiazide is approximately additive.

Although black hypertensive patients (usually a low-renin hypertensive population) usually have a smaller than average response to enalapril monotherapy than non-black patients, combination therapy with enalapril plus hydrochlorothiazide is equally effective in black and non-black patients.

Enalapril hydrochlorothiazide (Vaseretic) was granted final FDA approval for the treatment of hypertension on June 11, 1997.

Indications

• hypertension

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. angina
6. angioedema
7. anorexia
8. anosmia
9. anuria
10. aplastic anemia
11. arthralgia
12. asthenia
13. ataxia
14. atrial fibrillation
15. atrial tachycardia
16. azotemia
17. back pain
18. blurred vision
19. bradycardia
20. bronchospasm
21. cardiac arrest
22. chest pain (unspecified)
23. confusion
24. conjunctivitis
25. constipation
26. cough
27. depression
28. diaphoresis
29. diarrhea
30. dizziness
31. drowsiness
32. dysesthesia
33. dysgeusia
34. dyspepsia
35. dyspnea
36. elevated hepatic enzymes
37. eosinophilia
38. erythema multiforme
39. exfoliative dermatitis
40. fatigue
41. fever
42. flatulence
43. flushing
44. glossitis
45. gout
46. gynecomastia
47. headache
48. hemolytic anemia
49. hepatic failure
50. hepatic necrosis
51. hepatitis
52. hoarseness
53. hyperbilirubinemia
54. hypercalcemia
55. hypercholesterolemia
56. hyperglycemia
57. hyperkalemia
58. hypertriglyceridemia
59. hyperuricemia
60. hypomagnesemia
61. hypotension
62. hypovolemia
63. ileus
64. impotence (erectile dysfunction)
65. insomnia
66. jaundice
67. lacrimation
68. laryngeal edema
69. leukocytosis
70. leukopenia
71. libido decrease
72. melena
73. muscle cramps
74. myalgia
75. myocardial infarction
76. myopia
77. nausea
78. nephrolithiasis
79. neutropenia
80. ocular hypertension
81. oliguria
82. orthostatic hypotension
83. palpitations
84. pancreatitis
85. pancytopenia
86. paresthesias
87. pemphigus
88. periarteritis
89. peripheral neuropathy
90. photosensitivity
91. pneumonitis
92. pruritus
93. pulmonary edema
94. pulmonary embolism
95. purpura
96. rash
97. renal failure (unspecified)
98. restlessness
99. rhinorrhea
100. sialadenitis
101. sinus tachycardia
102. Stevens-Johnson syndrome
103. stomatitis
104. stroke
105. syncope
106. teratogenesis
107. thrombocytopenia
108. tinnitus
109. toxic epidermal necrolysis
110. urticaria
111. vasculitis
112. vertigo
113. vomiting
114. xanthopsia
115. xerophthalmia
116. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• serum creatinine/BUN
• serum electrolytes

Contraindications

• ACE-inhibitor induced angioedema
• Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
• anuria
• aortic stenosis
• asthma
• autoimmune disease
• Black patients
• bone marrow suppression
• breast-feeding
• cardiomyopathy
• cerebrovascular disease
• children
• collagen-vascular disease
• coronary artery disease
• diabetes mellitus
• dialysis
• electrolyte imbalance
• geriatric
• gout
• heart failure
• hepatic disease
• hereditary angioedema
• history of angioedema
• hymenoptera venom (insect sting) allergy desensitization
• hypercalcemia
• hyperglycemia
• hyperkalemia
• hyperuricemia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• immunosuppression
• low-density lipoprotein apheresis
• orthostatic hypotension
• pancreatitis
• penicillin hypersensitivity
• pregnancy
• renal artery stenosis
• renal disease
• renal failure
• renal impairment
• scleroderma
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alemtuzumab
• Alendronate; Cholecalciferol
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Allopurinol
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Amiodarone
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine; Dextroamphetamine Salts
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Amyl Nitrite
• Angiotensin II
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Apraclonidine
• Aprotinin
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Atracurium
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azathioprine
• Azilsartan
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Benztropine
• Beta-agonists
• Bortezomib
• Bosentan
• Brexpiprazole
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Cabergoline
• Calcium
• Calcium Phosphate, Supersaturated
• Calcium; Vitamin D
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Cariprazine
• Carvedilol
• Celecoxib
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpropamide
• Cholestyramine
• Cidofovir
• Cisapride
• Cisatracurium
• Citalopram
• Clindamycin; Tretinoin
• Clozapine
• Co-Enzyme Q10, Ubiquinone
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine; Probenecid
• Colestipol
• Conivaptan
• Corticosteroids
• Cosyntropin
• Cyclophosphamide
• Cyclosporine
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Desloratadine; Pseudoephedrine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexlansoprazole
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Quinidine
• Diazoxide
• Dichlorphenamide
• Diclofenac
• Diclofenac; Misoprostol
• Dicyclomine
• Diethylpropion
• Diflunisal
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dobutamine
• Dofetilide
• Dolasetron
• Donepezil; Memantine
• Dopamine
• Doxacurium
• Droperidol
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dulaglutide
• Duloxetine
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enflurane
• Entecavir
• Ephedrine
• Epinephrine
• Eplerenone
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergocalciferol, Vitamin D2
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esomeprazole
• Esomeprazole; Naproxen
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Ethanol
• Etodolac
• Etomidate
• Everolimus
• Exenatide
• Famotidine; Ibuprofen
• Fenoprofen
• Fentanyl
• Fexofenadine; Pseudoephedrine
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Flavoxate
• Fluconazole
• Fluocinolone; Hydroquinone; Tretinoin
• Fluorescein
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurbiprofen
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Gallium Ga 68 Dotatate
• General anesthetics
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Gold
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Halobetasol; Tazarotene
• Halofantrine
• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Ibuprofen
• Ibuprofen lysine
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Icatibant
• Icosapent ethyl
• Iloperidone
• Iloprost
• Inamrinone
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Indomethacin
• Inotersen
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Intravenous Lipid Emulsions
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Iron Dextran
• Isocarboxazid
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isoproterenol
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
• Isosulfan Blue
• Kanamycin
• Ketamine
• Ketoprofen
• Ketorolac
• Lansoprazole
• Lansoprazole; Naproxen
• Lanthanum Carbonate
• Lesinurad; Allopurinol
• Levalbuterol
• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine; Pseudoephedrine
• Losartan
• Lovastatin; Niacin
• Lurasidone
• Magnesium Salts
• Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
• Mannitol
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
• Meloxicam
• Memantine
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methotrexate
• Methoxsalen
• Methscopolamine
• Methylphenidate
• Metoclopramide
• Midodrine
• Miglitol
• Milnacipran
• Milrinone
• Mirtazapine
• Mivacurium
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nebivolol; Valsartan
• Nefazodone
• Nesiritide, BNP
• Neuromuscular blockers
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitrates
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nonsteroidal antiinflammatory drugs
• Norepinephrine
• Octreotide
• Olanzapine
• Olmesartan
• Olodaterol
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oprelvekin, rh-IL-11
• Oxaprozin
• Oxybutynin
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Paliperidone
• Pancuronium
• Pantoprazole
• Paroxetine
• Pasireotide
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentoxifylline
• Perindopril
• Perindopril; Amlodipine
• Phendimetrazine
• Phenelzine
• Phenothiazines
• Phentermine
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
• Pimozide
• Pioglitazone
• Pirbuterol
• Piroxicam
• Polycarbophil
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Porfimer
• Potassium
• Potassium Phosphate
• Potassium Phosphate; Sodium Phosphate
• Pramlintide
• Prazosin
• Pregabalin
• Prilocaine; Epinephrine
• Probenecid
• Procainamide
• Procaine
• Propantheline
• Propofol
• Pseudoephedrine
• Quetiapine
• Quinapril
• Quinidine
• Rabeprazole
• Ramipril
• Rapacuronium
• Rasagiline
• Remifentanil
• Repaglinide
• Rifampin
• Risperidone
• Rocuronium
• Rofecoxib
• Rosiglitazone
• Sacubitril; Valsartan
• Salicylates
• Salmeterol
• Saxagliptin
• Scopolamine
• Selegiline
• Semaglutide
• Serotonin norepinephrine reuptake inhibitors
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Silodosin
• Simvastatin; Sitagliptin
• Sirolimus
• Sitagliptin
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Spironolactone
• Streptozocin
• Succinylcholine
• Sufentanil
• Sulfacetamide
• Sulfacetamide; Sulfur
• Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
• Sulfinpyrazone
• Sulfonylureas
• Sulindac
• Tacrolimus
• Tapentadol
• Tazarotene
• Tegaserod
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• Telbivudine
• Telmisartan
• Temsirolimus
• Terbutaline
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• Tetracaine
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• Tolazamide
• Tolbutamide
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• Tolvaptan
• Topiramate
• Toremifene
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
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• Triamterene
• Trihexyphenidyl
• Trimethoprim
• Trospium
• Tubocurarine
• Umeclidinium; Vilanterol
• Valdecoxib
• Valsartan
• Vasopressin, ADH
• Vecuronium
• Venlafaxine
• Verteporfin
• Vilazodone
• Vitamin D
• Vitamin D analogs
• Vorinostat
• Vortioxetine
• Yohimbine
• Ziconotide
• Ziprasidone