Emtricitabine Brand Name– Emtriva
What is Emtricitabine
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for use with other antiretroviral medications to treat HIV-1 infections.
Emtricitabine belongs to the same nucleoside series as lamivudine, and therefore, should not be used in individuals who display resistance to lamivudine.
Before starting emtricitabine, all potential drug recipients should be tested for the presence of chronic hepatitis B virus (HBV).
The package labeling contains a Black Box Warning that severe, acute HBV exacerbations have been reported in HIV and HBV coinfected patients who discontinue use of emtricitabine.
Closely monitor any HIV and HBV coinfected patient who discontinues emtricitabine for several months for signs and symptoms of worsening hepatitis infection
Indications
- hepatitis B infection
- hepatitis B virus
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) prophylaxis
Side Effects
- abdominal pain
- anemia
- arthralgia
- asthenia
- bullous rash
- cough
- depression
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- exfoliative dermatitis
- fatigue
- fever
- glycosuria
- headache
- hematuria
- hepatic decompensation
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- hypoglycemia
- infection
- insomnia
- lactic acidosis
- maculopapular rash
- myalgia
- nausea
- neuritis
- neutropenia
- paresthesias
- peripheral neuropathy
- pharyngitis
- pruritus
- rash
- rhinitis
- sinusitis
- skin hyperpigmentation
- steatosis
- urticaria
- vesicular rash
- vomiting
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum lipid profile
- urinalysis
Contraindications
- alcoholism
- autoimmune disease
- breast-feeding
- children
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- infants
- neonates
- obesity
- pregnancy
- renal failure
- renal impairment
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acyclovir
- Adefovir
- Alogliptin; Metformin
- Amikacin
- Aminoglycosides
- Amlodipine; Celecoxib
- Canagliflozin; Metformin
- Celecoxib
- Cidofovir
- Dapagliflozin; Metformin
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Dolutegravir; Lamivudine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Echinacea
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Ertugliflozin; Metformin
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- food
- Foscarnet
- Ganciclovir
- Gentamicin
- Glipizide; Metformin
- Glyburide; Metformin
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Interferon Alfa-2b; Ribavirin
- Interferons
- Kanamycin
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Linagliptin; Metformin
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Orlistat
- Oxaprozin
- Paromomycin
- Piroxicam
- Plazomicin
- Ribavirin
- Rofecoxib
- Streptomycin
- Sulindac
- Tacrolimus
- Tobramycin
- Tolmetin
- Valacyclovir
- Valdecoxib
- Valganciclovir
