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Efavirenz Lamivudine Tenofovir Disoproxil Fumarate Brand Names- SYMFI | SYMFI LO
What is Efavirenz Lamivudine Tenofovir Disoproxil Fumarate
Efavirenz lamivudine tenofovir disoproxil fumarate is approved for the treatment of human immunodeficiency virus type 1 (HIV-1) in adult and pediatric patients weighing at least 35 kg (Symfi Lo) or 40 kg (Symfi).
Symfi Lo contains a lower dose of efavirenz (400 mg) compared with Symfi (600 mg).
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI), lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI), and tenofovir disoproxil fumarate is an acyclic nucleoside analog (i.e., nucleotide reverse transcriptase inhibitor).
This combination product allows for once daily dosing using a single tablet.
Although lamivudine and tenofovir disoproxil fumarate both exhibit activity against the hepatitis B virus (HBV), this drug is not indicated to treat HBV.
The FDA approved package labeling has a Black Box Warning stating that severe, acute exacerbations of hepatitis B have been reported in patients with HBV and HIV coinfection and have discontinued either lamivudine or tenofovir.
If treatment for HIV with efavirenz; lamivudine; tenofovir disoproxil fumarate is discontinued in a patient with HBV coinfection, the patient should be closely monitored for several months for signs and symptoms of worsening hepatitis infection.
Due to the similarities between emtricitabine and lamivudine, lamivudine containing products are not likely to be effective in individuals who display antimicrobial resistance to emtricitabine
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
NOTE: HIV guidelines recommend consideration be given to avoiding use of efavirenz-containing regimens in patients with pre-existing psychiatric illnesses, HIV-associated dementia (HAD), prolongation of the QTc interval, or who are receiving methadone as narcotic replacement therapy.
NOTE: Data are insufficient to recommend use of efavirenz (400 mg formulation); lamivudine; tenofovir disoproxil fumarate (Symfi Lo) in patients receiving concurrent treatment with rifampin. HIV guidelines recommend use of efavirenz (600 mg formulation); lamivudine; tenofovir disoproxil fumarate (Symfi) in patients receiving concurrent treatment with rifampin.
NOTE: HIV guidelines recommend consideration be given to avoiding use of tenofovir disoproxil fumarate-containing regimens in patients with renal disease and osteoporosis.
Side Effects
- abdominal pain
- abnormal dreams
- agitation
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- asthenia
- ataxia
- back pain
- bone fractures
- bone pain
- breast enlargement
- constipation
- Cushingoid features
- depression
- diabetes insipidus
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- emotional lability
- encephalopathy
- erythema multiforme
- Fanconi syndrome
- fever
- flushing
- folliculitis
- gynecomastia
- hallucinations
- headache
- hematuria
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- hypoesthesia
- hypokalemia
- hypophosphatemia
- infection
- insomnia
- interstitial nephritis
- lactic acidosis
- lipodystrophy
- maculopapular rash
- mania
- myalgia
- myopathy
- nausea
- neuritis
- neutropenia
- nightmares
- osteomalacia
- osteopenia
- osteoporosis
- palpitations
- pancreatitis
- paranoia
- paresthesias
- peripheral neuropathy
- pharyngitis
- photosensitivity
- polyuria
- proteinuria
- pruritus
- psychosis
- QT prolongation
- rash
- renal failure (unspecified)
- renal tubular necrosis
- rhabdomyolysis
- seizures
- skin ulcer
- steatosis
- Stevens-Johnson syndrome
- suicidal ideation
- teratogenesis
- tinnitus
- tremor
- urticaria
- vertigo
- vesicular rash
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- serum phosphate
- serum triglycerides
- urinalysis
Contraindications
- alcoholism
- Asian patients
- autoimmune disease
- bipolar disorder
- Black patients
- bone fractures
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- contraception requirements
- coronary artery disease
- depression
- diabetes mellitus
- driving or operating machinery
- exfoliative dermatitis
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- heart failure
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatomegaly
- hepatotoxicity or lactic acidosis
- Hispanic patients
- human immunodeficiency virus (HIV) infection resistance
- hypercholesterolemia
- hyperlipidemia
- hypertension
- hypertriglyceridemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- immune reconstitution syndrome
- laboratory test interference
- long QT syndrome
- malnutrition
- mania
- myocardial infarction
- neurotoxicity
- obesity
- osteomalacia
- osteoporosis
- pancreatitis
- peripheral neuropathy
- pregnancy
- pregnancy testing
- psychosis
- QT prolongation
- renal disease
- renal failure
- renal impairment
- schizophrenia
- seizure disorder
- seizures
- serious rash
- substance abuse
- suicidal ideation
- thyroid disease
- use with ribavirin
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Acyclovir
- Adefovir
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alprazolam
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amprenavir
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Avanafil
- Avapritinib
- Axitinib
- Azithromycin
- Bacitracin
- Barbiturates
- Bedaquiline
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Bosentan
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Cabozantinib
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carboplatin
- Cariprazine
- Carisoprodol
- Carvedilol
- Caspofungin
- Celecoxib
- Ceritinib
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cilostazol
- Ciprofloxacin
- Cisapride
- Cisplatin
- Citalopram
- Clarithromycin
- Clofarabine
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclophosphamide
- Cyclosporine
- Daclatasvir
- Dapagliflozin; Metformin
- Dapsone
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Disopyramide
- Disulfiram
- Docetaxel
- Dofetilide
- Dolasetron
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Echinacea
- Efavirenz; Emtricitabine; Tenofovir
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Eplerenone
- Erdafitinib
- Eribulin
- Erlotinib
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etodolac
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Famotidine; Ibuprofen
- Fedratinib
- Felodipine
- Fenoprofen
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fostamatinib
- Ganciclovir
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gentamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyprogesterone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Indomethacin
- Inotuzumab Ozogamicin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Interferon Gamma-1b
- Interferons
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lemborexant
- Lenvatinib
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobupivacaine
- Levofloxacin
- Levomethadyl
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Magnesium Salicylate
- Maprotiline
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Memantine
- Meperidine; Promethazine
- Mestranol; Norethindrone
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Moxifloxacin
- Nabumetone
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nefazodone
- Nelfinavir
- Neratinib
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Non-Ionic Contrast Media
- Non-oral combination contraceptives
- Nonsteroidal antiinflammatory drugs
- Norethindrone
- Norgestrel
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oral Contraceptives
- Oritavancin
- Orlistat
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Palbociclib
- Pamidronate
- Panobinostat
- Paricalcitol
- Paromomycin
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Pemigatinib
- Pentamidine
- Perampanel
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Piroxicam
- Pitolisant
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Praziquantel
- Primaquine
- Probenecid
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Red Yeast Rice
- Regorafenib
- Repaglinide
- Ribavirin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Riluzole
- Rimegepant
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Roflumilast
- Rolapitant
- Romidepsin
- Rucaparib
- Ruxolitinib
- Salicylates
- Salmeterol
- Salsalate
- Sapropterin
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Somatropin, rh-GH
- Sonidegib
- Sorafenib
- Sorbitol
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sufentanil
- Sulindac
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tafamidis
- Tamoxifen
- Tasimelteon
- Tazemetostat
- Tedizolid
- Telaprevir
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Terbinafine
- Terbutaline
- Testosterone
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thioridazine
- Ticagrelor
- Tiotropium; Olodaterol
- Tipranavir
- Tobramycin
- Tolbutamide
- Tolmetin
- Tolterodine
- Tolvaptan
- Toremifene
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimetrexate
- Trimipramine
- Triptorelin
- Trospium
- Tucatinib
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Vancomycin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vorapaxar
- Voriconazole
- Vorinostat
- Voxelotor
- Warfarin
- Zanubrutinib
- Ziprasidone
- Zoledronic Acid
- Zolpidem
- Zonisamide
