Econazole

Econazole Brand Names

Ecoza | Spectazole | Zolpak

What is Econazole

Econazole is an imidazole antifungal agent available for topical use. It differs structurally from miconazole in the absence of a chlorine atom at the 2 position of the phenylmethoxy group.

Econazole is used primarily to treat cutaneous candidiasis and tinea infections, including tinea versicolor. In vitro, the activity of econazole against dermatophytes and Candida albicans appears to be similar to that of clotrimazole, miconazole, or tioconazole.

Although econazole has been used effectively for the treatment of vulvovaginal candidiasis, an intravaginal preparation is not commercially available in the US.

This drug was approved by the FDA in 1982.

Indications

  1. Candida albicans
  2. Candida guilliermondii
  3. Candida parapsilosis
  4. Candida tropicalis
  5. candidiasis
  6. Epidermophyton floccosum
  7. Malassezia furfur
  8. Microsporum audouinii
  9. Microsporum canis
  10. Microsporum gypseum
  11. tinea corporis
  12. tinea cruris
  13. tinea pedis
  14. tinea versicolor
  15. Trichophyton mentagrophytes
  16. Trichophyton rubrum
  17. Trichophyton tonsurans
  18. Trichophyton verrucosum

Side Effects

  1. erythema
  2. pruritus
  3. rash
  4. skin irritation

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • ophthalmic administration
  • pregnancy
  • tobacco smoking
  • vaginal administration

Interactions

  • Corticosteroids
  • Nystatin
  • Warfarin
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