Drospirenone Brand Name– Slynd
What is Drospirenone
Drospirenone is a fourth generation progestin and an analog of spironolactone with antimineralocorticoid and antiandrogenic properties.
Drospirenone-only contraceptive regimens prevent pregnancy in females of reproductive potential. In women desiring oral contraception, drospirenone also improves acne in some women due to its antiandrogenic effects.
Hormonal progestin-only contraceptives can be used in female patients from menarche to over the age of 40 years up until the time of menopause with proper selection of products.
The choice of a routine hormonal contraceptive for any given patient is based on the individual’s contraceptive needs, underlying medical conditions or risk factors for adverse effects, and individual preferences for use.
The Centers for Disease Control’s U.S. Medical Eligibility Criteria describe considerations for risk vs. benefits, including medical conditions or attributes that contraindicate use; these criteria can help prescribing practitioners in product selection for individual patients.
Drospirenone may increase potassium levels in some patients; do not use drospirenone products in patients with significant risks for hyperkalemia, such as those with kidney, liver, or adrenal insufficiency.
Patients taking drugs that could increase serum potassium should consult their health care professional before taking drospirenone-containing oral contraceptive products.
A drospirenone-only oral contraceptive was FDA-approved in May 2019.
Indications
- contraception
For routine contraception
Side Effects
- acne vulgaris
- amenorrhea
- breakthrough bleeding
- breast discharge
- breast enlargement
- dysmenorrhea
- galactorrhea
- headache
- hyperkalemia
- lactation suppression
- libido decrease
- mastalgia
- menorrhagia
- menstrual irregularity
- nausea
- oligomenorrhea
- pelvic pain
- weight gain
Monitoring Parameters
- pap smear
- pelvic exam
- serum creatinine
- serum potassium
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- adrenal insufficiency
- breast cancer
- breast-feeding
- cervical cancer
- children
- depression
- diabetes mellitus
- ectopic pregnancy
- headache
- hepatic disease
- hepatocellular cancer
- human immunodeficiency virus (HIV) infection
- hyperkalemia
- jaundice
- menstrual irregularity
- migraine
- myocardial infarction
- osteopenia
- pregnancy
- renal disease
- renal failure
- renal impairment
- sexually transmitted disease
- stroke
- thromboembolic disease
- thromboembolism
- tobacco smoking
- uterine cancer
- vaginal bleeding
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetohexamide
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amobarbital
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Amprenavir
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Aztreonam
- Bacitracin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bosentan
- Bromocriptine
- Butabarbital
- Calaspargase pegol
- Canagliflozin; Metformin
- Carbamazepine
- Carbapenems
- Carbenicillin
- Cefaclor
- Cefadroxil
- Cefazolin
- Cefdinir
- Cefditoren
- Cefepime
- Cefiderocol
- Cefixime
- Cefotaxime
- Cefotetan
- Cefoxitin
- Cefpodoxime
- Cefprozil
- Ceftaroline
- Ceftazidime
- Ceftazidime; Avibactam
- Ceftibuten
- Ceftizoxime
- Ceftolozane; Tazobactam
- Ceftriaxone
- Cefuroxime
- Cenobamate
- Cephalexin
- Charcoal
- Chenodiol
- Chloramphenicol
- Chlorpropamide
- Ciprofloxacin
- Clarithromycin
- Clindamycin
- Clobazam
- Cobicistat
- Colistimethate, Colistin, Polymyxin E
- Conivaptan
- Dabrafenib
- Dalbavancin
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daptomycin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deferasirox
- Delafloxacin
- Delavirdine
- Demeclocycline
- Dicloxacillin
- Doripenem
- Doxycycline
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enasidenib
- Encorafenib
- Enzalutamide
- Eplerenone
- Eravacycline
- Ertapenem
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Felbamate
- Fidaxomicin
- Flibanserin
- Fluvoxamine
- Fosamprenavir
- Gemifloxacin
- Gentamicin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycylcyclines
- grapefruit juice
- Griseofulvin
- Heparin
- Hydantoins
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Idelalisib
- Imipenem; Cilastatin
- Imipenem; Cilastatin; Relebactam
- Incretin Mimetics
- Indinavir
- Insulins
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isotretinoin
- Itraconazole
- Ivosidenib
- Kanamycin
- Ketoconazole
- Lamotrigine
- Lefamulin
- Leflunomide
- Lesinurad
- Lesinurad; Allopurinol
- Levofloxacin
- Linagliptin
- Linagliptin; Metformin
- Lincomycin
- Lincosamides
- Linezolid
- Lomitapide
- Lorlatinib
- Lumacaftor; Ivacaftor
- Meglitinides
- Mephobarbital
- Meropenem
- Meropenem; Vaborbactam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Metronidazole
- Mifepristone
- Miltefosine
- Minocycline
- Mitotane
- Mivacurium
- Modafinil
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nafcillin
- Nefazodone
- Nelfinavir
- Neomycin
- Nevirapine
- Nitrofurantoin
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Ofloxacin
- Omadacycline
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Oxacillin
- Oxcarbazepine
- Paromomycin
- Pegaspargase
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Pentobarbital
- Pexidartinib
- Phenobarbital
- Phentermine; Topiramate
- Piperacillin
- Piperacillin; Tazobactam
- Pitolisant
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Potassium
- Potassium-sparing diuretics
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Primidone
- Pyrimethamine; Sulfadoxine
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Riluzole
- Roflumilast
- Rufinamide
- Saquinavir
- Sarilumab
- Saxagliptin
- Secobarbital
- Siltuximab
- Simvastatin; Sitagliptin
- Sitagliptin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptomycin
- Succinylcholine
- Sugammadex
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Sulfonylureas
- Tazemetostat
- Tedizolid
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Teriflunomide
- Tetracycline
- Thalidomide
- Thiopental
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Tigecycline
- Tinidazole
- Tipranavir
- Tizanidine
- Tobramycin
- Tocilizumab
- Tolazamide
- Tolbutamide
- Topiramate
- Triamterene
- Trimethoprim
- Tucatinib
- Ulipristal
- Vancomycin
- Voriconazole
