Dorzolamide Timolol

Dorzolamide Timolol Brand Name– Cosopt | Cosopt PF

What is Dorzolamide Timolol

Dorzolamide and timolol are combined in an ophthalmic solution for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who have not adequately responded to topical beta-blockers alone.

Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta-blocker. Dorzolamide timolol given twice daily, reduces IOP to a greater extent than ophthalmic administration of either dorzolamide or timolol alone.

However, the IOP reduction observed with twice daily dorzolamide; timolol is slightly less than that seen with concomitant administration of 0.5% timolol given twice daily and 2% dorzolamide given three times per day.

Cosopt ophthalmic solution (2% dorzolamide; 0.5% timolol) was approved by the FDA in April 1998 and a preservative-free formulation (Cosopt PF) was approved in February 2012.

Indications

• glaucoma
• ocular hypertension

For the treatment of glaucoma or ocular hypertension in patients who are insufficiently responsive to beta-blockers

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. angina
6. angioedema
7. anorexia
8. anxiety
9. aplastic anemia
10. arrhythmia exacerbation
11. arthralgia
12. asthenia
13. back pain
14. blepharedema
15. blepharitis
16. blurred vision
17. bradycardia
18. bronchospasm
19. cardiac arrest
20. cataracts
21. chest pain (unspecified)
22. colitis
23. confusion
24. conjunctival hyperemia
25. conjunctivitis
26. contact dermatitis
27. corneal edema
28. corneal erosion
29. corneal opacification
30. cough
31. depression
32. diaphoresis
33. diarrhea
34. diplopia
35. dizziness
36. drowsiness
37. dysgeusia
38. dyspepsia
39. dyspnea
40. edema
41. emotional lability
42. epistaxis
43. erythema
44. fatigue
45. fever
46. foreign body sensation
47. hallucinations
48. headache
49. heart failure
50. hepatic necrosis
51. hepatomegaly
52. hyperglycemia
53. hypertension
54. hypoglycemia
55. hypotension
56. impotence (erectile dysfunction)
57. infection
58. influenza
59. insomnia
60. keratitis
61. lacrimation
62. laryngospasm
63. libido decrease
64. macular edema
65. memory impairment
66. myalgia
67. myasthenia
68. myocardial infarction
69. myopia
70. nasal congestion
71. nausea
72. nightmares
73. ocular irritation
74. ocular pain
75. ocular pruritus
76. palpitations
77. paresthesias
78. pharyngitis
79. photophobia
80. pruritus
81. psoriaform rash
82. psoriasis
83. ptosis
84. pulmonary edema
85. purpura
86. rash
87. retroperitoneal fibrosis
88. sinusitis
89. skin hyperpigmentation
90. skin irritation
91. Stevens-Johnson syndrome
92. syncope
93. tinnitus
94. toxic epidermal necrolysis
95. urticaria
96. vertigo
97. visual impairment
98. vomiting
99. weakness
100. xerophthalmia
101. xerostomia

Monitoring Parameters

• intraocular pressure

Contraindications

• acute bronchospasm
• asthma
• AV block
• bradycardia
• breast-feeding
• bronchitis
• carbonic anhydrase inhibitor hypersensitivity
• cardiac disease
• cardiogenic shock
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• contact lenses
• corneal abrasion
• coronary artery disease
• diabetes mellitus
• emphysema
• geriatric
• heart failure
• hepatic disease
• hyperthyroidism
• hypoglycemia
• hypotension
• infants
• neonates
• ocular infection
• peripheral vascular disease
• pregnancy
• pulmonary disease
• Raynaud’s phenomenon
• renal disease
• renal failure
• renal impairment
• sick sinus syndrome
• sulfonamide hypersensitivity
• surgery
• thyrotoxicosis
• vasospastic angina
• ventricular dysfunction

Interactions

• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Propoxyphene
• Adenosine
• Albiglutide
• Aldesleukin, IL-2
• Alemtuzumab
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Alogliptin; Metformin
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Amiodarone
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amyl Nitrite
• Antithyroid agents
• Apomorphine
• Apraclonidine
• Aripiprazole
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atazanavir
• Atazanavir; Cobicistat
• Baclofen
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Beta-agonists
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bosentan
• Bretylium
• Brexpiprazole
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Bupropion
• Bupropion; Naltrexone
• Cabergoline
• Caffeine; Ergotamine
• Canagliflozin; Metformin
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Cariprazine
• Ceritinib
• Cevimeline
• Chloroprocaine
• Chlorthalidone; Clonidine
• Choline Salicylate; Magnesium Salicylate
• Cimetidine
• Cinacalcet
• Citalopram
• Clevidipine
• Clonidine
• Clozapine
• Co-Enzyme Q10, Ubiquinone
• Cobicistat
• Cocaine
• Colesevelam
• Conivaptan
• Crizotinib
• Dapagliflozin; Metformin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desflurane
• Dexmedetomidine
• Dextromethorphan; Quinidine
• Diazoxide
• Digoxin
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Dipyridamole
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Doxazosin
• Dronedarone
• Dulaglutide
• Duloxetine
• Dutasteride; Tamsulosin
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Felodipine
• Encainide
• Enflurane
• Epoprostenol
• Ergonovine
• Ergotamine
• Ertugliflozin; Metformin
• Escitalopram
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Etomidate
• Exenatide
• Felodipine
• Fenoldopam
• Fingolimod
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Flecainide
• Fluorescein
• Fluoxetine
• Fluoxetine; Olanzapine
• food
• Fospropofol
• Galantamine
• General anesthetics
• Ginger, Zingiber officinale
• Glipizide; Metformin
• Glucagon
• Glyburide; Metformin
• Guanabenz
• Guanfacine
• Haloperidol
• Halothane
• Hydralazine; Isosorbide Dinitrate, ISDN
• Icosapent ethyl
• Iloperidone
• Iloprost
• Imatinib
• Incretin Mimetics
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Intravenous Lipid Emulsions
• Iobenguane I 131
• Isocarboxazid
• Isoflurane
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
• Isradipine
• Ivabradine
• Ketamine
• Lacosamide
• Lanreotide
• Lasmiditan
• Levobupivacaine
• Levodopa
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lithium
• Lixisenatide
• Lofexidine
• Lopinavir; Ritonavir
• Lovastatin; Niacin
• Lurasidone
• Magnesium Salicylate
• Mefloquine
• Meglitinides
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Mestranol; Norethindrone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methacholine
• Methohexital
• Methylergonovine
• Methysergide
• Milrinone
• Mirabegron
• Nefazodone
• Nesiritide, BNP
• Neuromuscular blockers
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nonsteroidal antiinflammatory drugs
• Octreotide
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Oritavancin
• Oxymetazoline
• Paliperidone
• Paroxetine
• Pasireotide
• Peginterferon Alfa-2b
• Pentoxifylline
• Perindopril; Amlodipine
• Phenelzine
• Phenothiazines
• Phenoxybenzamine
• Phentolamine
• Pilocarpine
• Pramlintide
• Prazosin
• Prilocaine
• Prilocaine; Epinephrine
• Procainamide
• Procaine
• Propafenone
• Propofol
• Propoxyphene
• Quinidine
• Quinine
• Ranolazine
• Rasagiline
• Remifentanil
• Reserpine
• Risperidone
• Ritonavir
• Rivastigmine
• Rolapitant
• Ropivacaine
• Salsalate
• Selegiline
• Semaglutide
• Sevoflurane
• SGLT2 Inhibitors
• Silodosin
• Siponimod
• Sufentanil
• Sulfonylureas
• Sympathomimetics
• Tacrine
• Tamsulosin
• Tasimelteon
• Terazosin
• Tetrabenazine
• Tetracaine
• Thalidomide
• Thiazolidinediones
• Thiopental
• Thyroid hormones
• Tizanidine
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Vemurafenib
• Verapamil
• Yohimbine
• Ziprasidone