Dorzolamide

Dorzolamide Brand Name– Trusopt

What is Dorzolamide

Dorzolamide is a carbonic anhydrase inhibitor for the treatment of glaucoma and ocular hypertension.

A related carbonic anhydrase inhibitor, acetazolamide, has poor penetration when applied to the cornea, and thus is only administered systemically.

Dorzolamide represents the culmination of a decade of research for an effective topical carbonic anhydrase inhibitor.

Dorzolamide proved to be the most potent inhibitor in the group studied, showing good tolerability and effective lowering of IOP.

Since dorzolamide is not a beta-blocker, bradycardia and/or hypotension are less likely. Dorzolamide is a sulfonamide derivative and should not be administered to patients with sulfonamide hypersensitivity.

Dorzolamide 2% ophthalmic solution (Trusopt®) was approved by the FDA December 9, 1994; marketing began June 1995.

Indications

  • glaucoma
  • ocular hypertension

For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Side Effects

  1. agranulocytosis
  2. anaphylactoid reactions
  3. angioedema
  4. aplastic anemia
  5. asthenia
  6. blurred vision
  7. bronchospasm
  8. conjunctivitis
  9. contact dermatitis
  10. corneal edema
  11. dizziness
  12. dysgeusia
  13. dyspnea
  14. epistaxis
  15. headache
  16. hepatic necrosis
  17. keratitis
  18. lacrimation
  19. myopia
  20. nausea
  21. ocular irritation
  22. ocular pain
  23. paresthesias
  24. photophobia
  25. pruritus
  26. rash
  27. Stevens-Johnson syndrome
  28. throat irritation
  29. toxic epidermal necrolysis
  30. urticaria
  31. xerophthalmia
  32. xerostomia

Monitoring Parameters

  • intraocular pressure

Contraindications

  • breast-feeding
  • carbonic anhydrase inhibitor hypersensitivity
  • children
  • closed-angle glaucoma
  • contact lenses
  • corneal abrasion
  • geriatric
  • hepatic disease
  • infants
  • neonates
  • ocular infection
  • pregnancy
  • renal impairment
  • sulfonamide hypersensitivity

Interactions

There are no drug interactions associated with Dorzolamide products.

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