Dolutegravir

Dolutegravir Brand Name– TIVICAY | Tivicay PD

What is Dolutegravir

Dolutegravir is an HIV integrase strand transfer inhibitor (INSTI) indicated for use with other antiretroviral agents to treat human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral-naive or antiretroviral-experienced, but INSTI-naive, adults and pediatric patients 4 weeks and older weighing at least 3 kg.

The drug is also approved for use in adults who are INSTI-experienced with certain INSTI-associated resistance substitutions or clinically suspected resistance to other INSTIs; however, its use in pediatric patients with known or suspected INSTI resistance should be avoided, as efficacy has not been established in this population.

Finally, dolutegravir may be given with rilpivirine as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components.

The INSTI class of antiretrovirals is designed to slow the advancement of HIV infection by blocking the HIV integrase enzyme needed for viral multiplication.

Indications

  1. human immunodeficiency virus (HIV)
  2. human immunodeficiency virus (HIV) infection
  3. human immunodeficiency virus (HIV) prophylaxis

Side Effects

  • abdominal pain
  • anemia
  • anxiety
  • arthralgia
  • depression
  • diarrhea
  • dizziness
  • elevated hepatic enzymes
  • fatigue
  • flatulence
  • headache
  • hepatic failure
  • hepatitis
  • hyperbilirubinemia
  • hyperglycemia
  • hyperkalemia
  • insomnia
  • maculopapular rash
  • myalgia
  • nausea
  • neutropenia
  • pruritus
  • rash
  • suicidal ideation
  • teratogenesis
  • vomiting
  • weight gain

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • CD4+ T cell count
  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum bilirubin (total and direct)
  • serum cholesterol
  • serum creatinine
  • serum lipid profile
  • urinalysis

Contraindications

  • autoimmune disease
  • Black patients
  • breast-feeding
  • contraception requirements
  • depression
  • females
  • geriatric
  • Graves’ disease
  • Guillain-Barre syndrome
  • hepatic disease
  • hepatitis B and HIV coinfection
  • hepatitis C and HIV coinfection
  • Hispanic patients
  • human immunodeficiency virus (HIV) infection resistance
  • immune reconstitution syndrome
  • pregnancy
  • pregnancy testing
  • renal failure
  • reproductive risk
  • serious rash
  • suicidal ideation

Interactions

  • Acalabrutinib
  • Alogliptin; Metformin
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Bosentan
  • Brigatinib
  • Cabozantinib
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Canagliflozin; Metformin
  • Capmatinib
  • Carbamazepine
  • Carvedilol
  • Cenobamate
  • Ceritinib
  • Chromium
  • Clobazam
  • Cobicistat
  • Conivaptan
  • Daclatasvir
  • Dalfampridine
  • Dapagliflozin; Metformin
  • Darolutamide
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dofetilide
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enzalutamide
  • Ertugliflozin; Metformin
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Etravirine
  • Fedratinib
  • Felbamate
  • Fosamprenavir
  • Fosphenytoin
  • Fostamatinib
  • Fostemsavir
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Hetastarch; Dextrose; Electrolytes
  • Idelalisib
  • Iron
  • Iron Salts
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Letermovir
  • Linagliptin; Metformin
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Salts
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Mitotane
  • Modafinil
  • Nevirapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Osimertinib
  • Oxcarbazepine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Polysaccharide-Iron Complex
  • Primidone
  • Regorafenib
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Sapropterin
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sorafenib
  • St. John’s Wort, Hypericum perforatum
  • Sucralfate
  • Tafamidis
  • Tedizolid
  • Telotristat Ethyl
  • Temsirolimus
  • Tipranavir
  • Tolvaptan
  • Topiramate
  • Tucatinib
  • Voriconazole
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