Disulfiram Brand Name– Antabuse
What is Disulfiram
Disulfiram is used in the management of ethanol abuse. The drug is not a cure for alcoholism but rather is a deterrent to ethanol consumption.
Disulfiram should be used only in highly motivated individuals who are receiving psychotherapy concomitantly. The purpose of disulfiram therapy is to aid the patient in maintaining abstinence until adequate self-motivation has been established.
The effects of disulfiram in combination with ethanol were discovered accidentally by two Danish physicians investigating its use as an anthelmintic.
The drug was approved by the FDA in 1951 for use in the treatment of alcoholism.
Indications
- alcohol dependence
For the maintenance treatment of alcohol dependence
Side Effects
- acne vulgaris
- acute generalized exanthematous pustulosis (AGEP)
- atopic dermatitis
- blurred vision
- chest pain (unspecified)
- cholestasis
- confusion
- drowsiness
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- fatigue
- flushing
- headache
- heart failure
- hepatic failure
- hepatitis
- hyperhidrosis
- hypotension
- impotence (erectile dysfunction)
- jaundice
- nausea
- neuritis
- optic neuritis
- palpitations
- peripheral neuropathy
- psychosis
- respiratory depression
- seizures
- sinus tachycardia
- syncope
- vertigo
- vomiting
- weakness
Monitoring Parameters
- CBC
- LFTs
- serum electrolytes
Contraindications
- acute myocardial infarction
- breast-feeding
- cardiac disease
- diabetes mellitus
- ethanol ingestion
- ethanol intoxication
- hematological disease
- hepatic disease
- hepatitis
- hypothyroidism
- jaundice
- pregnancy
- psychosis
- renal disease
- seizure disorder
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Dichloralphenazone; Isometheptene
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Aprepitant, Fosaprepitant
- Ascorbic Acid, Vitamin C
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Benznidazole
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Bosentan
- Bupivacaine; Lidocaine
- Bupropion; Naltrexone
- Caffeine
- Caffeine; Ergotamine
- Chloral Hydrate
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorhexidine
- Chlorzoxazone
- Ciprofloxacin
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Cyclosporine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desipramine
- Diazepam
- Doxepin
- Doxercalciferol
- Dronabinol
- Dronedarone
- Duloxetine
- Dyphylline
- Dyphylline; Guaifenesin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Estazolam
- Ethanol
- Ethotoin
- Flurazepam
- Fosphenytoin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Green Tea
- Hydantoins
- Idelalisib
- Imipenem; Cilastatin
- Imipenem; Cilastatin; Relebactam
- Imipramine
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ixabepilone
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Maprotiline
- Meloxicam
- Mesoridazine
- Metronidazole
- Midazolam
- Mitotane
- Nabilone
- Naltrexone
- Netupitant, Fosnetupitant; Palonosetron
- Nortriptyline
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Paclitaxel
- Pazopanib
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenytoin
- Pimozide
- Pirfenidone
- Posaconazole
- Protriptyline
- Quazepam
- Ramelteon
- Rasagiline
- Riluzole
- Ritonavir
- Sertraline
- Sevoflurane
- Simeprevir
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Terbinafine
- Thalidomide
- Theophylline, Aminophylline
- Tinidazole
- Tipranavir
- Tranylcypromine
- Triazolam
- Tricyclic antidepressants
- Trimipramine
- Vemurafenib
- Voriconazole
- Warfarin
- Zalcitabine, ddC
