Dirithromycin Brand Name– Dynabac
What is Dirithromycin
Dirithromycin is an oral macrolide antibiotic similar to erythromycin.
Dirithromycin distinguishes itself from erythromycin by its improved pharmacokinetics and no apparent effect on the cytochrome P-450 hepatic enzyme system.
Dirithromycin’s spectrum of activity is similar to that of erythromycin, and both drugs are equally effective in treating community-acquired pneumonias.
Once-daily dosing for dirithromycin is possible due to the extensive tissue distribution of the active dirithromycin metabolite, erythromycylamine.
Dirithromycin was FDA-approved on June 19, 1995.
Indications
- Bacillus anthracis
- Bordetella parapertussis
- Bordetella pertussis
- bronchitis
- Campylobacter jejuni
- community-acquired pneumonia
- Corynebacterium diphtheriae
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Helicobacter pylori
- Legionella pneumophila
- lower respiratory tract infections
- Moraxella catarrhalis
- Mycoplasma pneumoniae
- pharyngitis
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- tonsillitis
- upper respiratory tract infections
Side Effects
- abdominal pain
- asthenia
- cough
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- eosinophilia
- flatulence
- headache
- hyperkalemia
- insomnia
- nausea
- pruritus
- pseudomembranous colitis
- rash
- thrombocytosis
- urticaria
- vertigo
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- colitis
- diarrhea
- geriatric
- GI disease
- hepatic disease
- inflammatory bowel disease
- macrolide hypersensitivity
- pregnancy
- pseudomembranous colitis
- sodium restriction
- ulcerative colitis
- viral infection
Interactions
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Caffeine; Ergotamine
- Dihydroergotamine
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Ergonovine
- Ergotamine
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- H2-blockers
- Mestranol; Norethindrone
- Methylergonovine
- Omeprazole; Sodium Bicarbonate
- Pimozide
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- Warfarin
