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Dexlansoprazole Brand Names- Dexilant | Kapidex
What is Dexlansoprazole
Dexlansoprazole is a proton-pump inhibitor (PPI) that inhibits gastric acid secretion.
It is the R-enantiomer of lansoprazole. Dexlansoprazole differs from other PPI formulations in that it has a dual delayed release delivery system that gives the drug two distinct drug release periods.
This technology was developed to extend the duration of acid-suppression in order to provide more effective coverage during the latter part of the 24-hour dosing interval.
Two clinical trials designed to test non-inferiority demonstrated that dexlansoprazole (60 mg PO daily) is as effective as lansoprazole (30 mg PO daily) in its ability to heal endoscopically confirmed erosive esophagitis. The potential benefits of the dual release formulation over conventional single release lansoprazole were tested in two separate studies; however, superiority was only demonstrated in one of the two studies.
On the basis of available research, no clear advantage has been demonstrated for the use of one PPI over another in the treatment of GERD. Instead, it is important to optimize the current treatment by considering twice daily dosing. A one-time switch to a different PPI in a refractory patient may be useful.
In January 2009, the FDA approved dexlansoprazole delayed-release oral capsules for the treatment of erosive esophagitis (EE) and symptomatic non-erosive gastroesophageal reflux disease (GERD).
In order to prevent confusion with drugs with similar names, in February 2010, the brand name of Kapidex was changed to Dexilant. In January 2016, a delayed-release disintegrating tablet formulation (Dexilant SoluTab) received FDA approval for maintenance of healed EE and treatment of non-erosive GERD.
Of note, the solutabs can not be used to heal EE and are not interchangeable with the delayed release capsules
Indications
- eosinophilic esophagitis
- esophagitis
- gastroesophageal reflux disease (GERD)
- pyrosis (heartburn)
For the symptomatic treatment of non-erosive gastroesophageal reflux disease (GERD), including treatment of pyrosis (heartburn) related to GERD
NOTE: Dexlansoprazole is not used for occasional heartburn.
Side Effects
- abdominal pain
- acne vulgaris
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angina
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- bezoar
- blurred vision
- bone fractures
- bradycardia
- candidiasis
- chest pain (unspecified)
- chills
- cholecystitis
- cholelithiasis
- colic
- colitis
- constipation
- cough
- dehydration
- depression
- diabetes mellitus
- diarrhea
- dizziness
- dysgeusia
- dysmenorrhea
- dyspareunia
- dyspepsia
- dysphagia
- dysphonia
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- epistaxis
- eructation
- erythema
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- flushing
- folliculitis
- gastric polyps
- gastritis
- goiter
- gout
- halitosis
- hallucinations
- headache
- hearing loss
- hematemesis
- hemolytic anemia
- hemorrhoids
- hepatitis
- hepatomegaly
- hiccups
- hyperbilirubinemia
- hypercalcemia
- hyperglycemia
- hyperlipidemia
- hypertension
- hyperventilation
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypothyroidism
- infection
- influenza
- insomnia
- interstitial nephritis
- jaundice
- libido decrease
- libido increase
- lupus-like symptoms
- lymphadenopathy
- memory impairment
- menorrhagia
- menstrual irregularity
- migraine
- muscle cramps
- musculoskeletal pain
- myalgia
- myocardial infarction
- nausea
- neutropenia
- ocular inflammation
- ocular irritation
- otalgia
- palpitations
- pancreatitis
- paresthesias
- pernicious anemia
- pharyngitis
- proctitis
- pruritus
- pseudomembranous colitis
- rash
- restless legs syndrome (RLS)
- seizures
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stroke
- tenesmus
- thrombocytopenia
- thrombosis
- tinnitus
- toxic epidermal necrolysis
- tremor
- urinary urgency
- urticaria
- vasculitis
- vertigo
- vitamin B12 deficiency
- vomiting
- weight gain
- xerostomia
Monitoring Parameters
- LFTs
- serum magnesium
Contraindications
- bone fractures
- breast-feeding
- diarrhea
- gastric cancer
- geriatric
- hepatic disease
- hypomagnesemia
- laboratory test interference
- long QT syndrome
- osteopenia
- osteoporosis
- pregnancy
- proton pump inhibitors (PPIs) hypersensitivity
- pseudomembranous colitis
- rebound acid hypersecretion
- systemic lupus erythematosus (SLE)
- vitamin B12 deficiency
Interactions
- Acalabrutinib
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Alendronate
- Alendronate; Cholecalciferol
- Amobarbital
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Ampicillin
- Ampicillin; Sulbactam
- Anticholinergics
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bisacodyl
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Butabarbital
- Calcium Carbonate; Risedronate
- Capecitabine
- Carbamazepine
- Cefpodoxime
- Ceftibuten
- Cefuroxime
- Ceritinib
- Chlordiazepoxide; Clidinium
- Ciprofloxacin
- Cobicistat
- Cyanocobalamin, Vitamin B12
- Cysteamine
- Dacomitinib
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Delavirdine
- Dexamethasone
- Dexmethylphenidate
- Dextroamphetamine
- Dicyclomine
- Digoxin
- Dolutegravir; Rilpivirine
- Dronedarone
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enzalutamide
- Erlotinib
- Eslicarbazepine
- Ethacrynic Acid
- Ethanol
- Fedratinib
- Flavoxate
- Fluvoxamine
- food
- Furosemide
- Gefitinib
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hydantoins
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indacaterol; Glycopyrrolate
- Iron
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Ledipasvir; Sofosbuvir
- Lefamulin
- Letermovir
- Loop diuretics
- Lopinavir; Ritonavir
- Luliconazole
- Lumacaftor; Ivacaftor
- Mefloquine
- Mepenzolate
- Mephobarbital
- Mesalamine, 5-ASA
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methotrexate
- Methscopolamine
- Methylphenidate
- Mitotane
- Modafinil
- Mycophenolate
- Nelfinavir
- Neratinib
- Nilotinib
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Oxybutynin
- Pazopanib
- Pentobarbital
- Phenobarbital
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Ponatinib
- Posaconazole
- Primidone
- Propantheline
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Rilpivirine
- Risedronate
- Ritonavir
- Saquinavir
- Scopolamine
- Secobarbital
- Secretin
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- St. John’s Wort, Hypericum perforatum
- Sucralfate
- Tacrolimus
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Thiazide diuretics
- Thiopental
- Thyroid hormones
- Tipranavir
- Tolterodine
- Torsemide
- Trihexyphenidyl
- Trospium
- Voriconazole
- Warfarin
