Dexamethasone Neomycin Polymyxin B

Dexamethasone Neomycin Polymyxin B Brand Names

AK-Trol | Dexacidin | Dexasporin | Gatol | Maxitrol | Methadex | NeoPolyDex | Ocu-Trol | Poly-Dex

What is Dexamethasone Neomycin Polymyxin B

Dexamethasone neomycin polymyxin B are used together in ophthalmic preparations to treat steroid-responsive inflammatory ocular conditions in which a corticosteroid is indicated and where bacterial infection or risk of bacterial infection exists. Dexamethasone is a glucocorticoid antiinflammatory agent.

Neomycin and polymyxin B are antimicrobial agents used to treat or prevent ocular bacterial infections.

When used together neomycin and polymyxin B displays activity against Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella species, Neisseria species, Pseudomonas aeruginosa, and Staphylococcus aureus.

Dexamethasone neomycin polymyxin B was first approved by the FDA as a suspension on June 1963; in July of the same year, 1963, the ointment formulation was approved

Indications

1. bacterial conjunctivitis
2. corneal abrasion
3. Enterobacter sp.
4. Escherichia coli
5. Haemophilus influenzae (beta-lactamase negative)
6. Haemophilus influenzae (beta-lactamase positive)
7. Klebsiella sp.
8. Neisseria sp.
9. ocular inflammation
10. Pseudomonas aeruginosa
11. Staphylococcus aureus (MSSA)
12. uveitis

Side Effects

1. anaphylactoid reactions
2. bullous rash
3. cataracts
4. conjunctival hyperemia
5. conjunctivitis
6. erythema
7. headache
8. impaired wound healing
9. keratitis
10. ocular hypertension
11. ocular infection
12. ocular irritation
13. ocular pruritus
14. pruritus
15. rash
16. Stevens-Johnson syndrome
17. superinfection
18. urticaria

Monitoring Parameters

• intraocular pressure
• ophthalmologic exam

Contraindications

• abrupt discontinuation
• aminoglycoside hypersensitivity
• breast-feeding
• cataracts
• children
• contact lenses
• corticosteroid hypersensitivity
• corticosteroid withdrawal
• fungal infection
• glaucoma
• herpes infection
• herpes simplex keratitis (dendritic keratitis)
• increased intraocular pressure
• infants
• intramuscular administration
• intravenous administration
• mycobacterial infection
• neomycin hypersensitivity
• neonates
• ocular infection
• ocular surgery
• polymyxin hypersensitivity
• pregnancy
• varicella
• viral infection
• visual disturbance

Interactions

There are no drug interactions associated with Dexamethasone; Neomycin; Polymyxin B products.