Darolutamide Brand Name– NUBEQA
What is Darolutamide
Darolutamide is an androgen receptor inhibitor. It works by competitively inhibiting androgen binding to androgen receptors, thus inhibiting nuclear translocation of androgen receptors and their interaction with DNA.
It is indicated for the treatment of patients with nonmetastatic castration-resistant prostate cancer, where it significantly prolonged metastasis-free survival; overall survival data were not mature at the time of FDA approval.
Darolutamide differs from other FDA-approved androgen receptor inhibitors (e.g., apalutamide, enzalutamide) in that it has a distinct structure with fewer side effects, thought to be due to low penetration of the blood-brain barrier and low binding affinity for gamma-aminobutyric acid type A receptors.
Indications
- prostate cancer
For the treatment of prostate cancer
for the treatment of nonmetastatic castration-resistant prostate cancer
Side Effects
- anemia
- anemia
- asthenia
- diarrhea
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- fatigue
- fatigue
- heart failure
- heart failure
- hot flashes
- hyperbilirubinemia
- hyperbilirubinemia
- hypertension
- hypertension
- lethargy
- maculopapular rash
- malaise
- musculoskeletal pain
- nausea
- nausea
- neutropenia
- neutropenia
- rash
- rash
- weight loss
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- contraception requirements
- females
- hepatic disease
- infertility
- male-mediated teratogenicity
- pregnancy
- renal disease
- renal failure
- reproductive risk
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Alpelisib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Carbamazepine
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Fosphenytoin
- Glecaprevir; Pibrentasvir
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Irinotecan
- Irinotecan Liposomal
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Methotrexate
- Mifepristone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Pazopanib
- Phenobarbital
- Phenytoin
- Posaconazole
- Prazosin
- Primidone
- Rifampin
- Rimegepant
- Ritonavir
- Rosuvastatin
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Sulfasalazine
- Talazoparib
- Telithromycin
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Topotecan
- Ubrogepant
- Vemurafenib
