Dalfopristin Quinupristin Brand Name– Synercid
What is Dalfopristin Quinupristin
Dalfopristin and quinupristin are members of a group of antibiotics known as streptogramins which are isolated from Streptomyces pristinaespiralis.
Streptogramin antibiotics have been used orally for many years in France, but Synercid represents the first injectable formulation.
When administered together, these antibiotics (also known as synergistins) appear to act synergistically against susceptible bacteria.
The combination product (Synercid) has up to 16 times the activity of each agent alone.
Synercid was approved for vancomycin-resistant Enterococcus faecium (VREF) bacteremia and for complicated skin and skin-structure infections due to methicillin-sensitive Staphylococcus aureus and Streptococcus pyogenes on September 21, 1999 under the FDA’s accelerated approval process.
In August 2010, the FDA removed the VREF bacteremia indication from the product labeling.
Indications
- bacteremia
- Corynebacterium jeikeium
- Enterococcus faecium
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anxiety
- apnea
- arthralgia
- bone pain
- candidiasis
- chest pain (unspecified)
- confusion
- constipation
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- encephalopathy
- fever
- GI bleeding
- gout
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hyperhidrosis
- hypertonia
- hypoglycemia
- hyponatremia
- hypotension
- hypoventilation
- hypovolemia
- hypoxia
- injection site reaction
- insomnia
- jaundice
- maculopapular rash
- myalgia
- myasthenia
- nausea
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral neuropathy
- peripheral vasodilation
- phlebitis
- pleural effusion
- pruritus
- pseudomembranous colitis
- rash
- seizures
- skin ulcer
- stomatitis
- stroke
- superinfection
- supraventricular tachycardia (SVT)
- syncope
- thrombosis
- tremor
- urticaria
- vaginitis
- ventricular fibrillation
- vomiting
Monitoring Parameters
- LFTs
Contraindications
- breast-feeding
- children
- colitis
- diarrhea
- geriatric
- GI disease
- hepatic disease
- infants
- inflammatory bowel disease
- neonates
- pregnancy
- pseudomembranous colitis
- streptogramin hypersensitivity
- ulcerative colitis
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Alfentanil
- Almotriptan
- Alosetron
- Alprazolam
- Amlodipine; Atorvastatin
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Caffeine; Ergotamine
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cisapride
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Cyclosporine
- Dapagliflozin; Saxagliptin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dextromethorphan; Quinidine
- Diazepam
- Dienogest; Estradiol valerate
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dofetilide
- Doxorubicin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Ergotamine
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Felodipine
- Fentanyl
- Flibanserin
- food
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Oxycodone
- Isradipine
- Ixabepilone
- Lemborexant
- Leuprolide; Norethindrone
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Mestranol; Norethindrone
- Metformin; Saxagliptin
- Methadone
- Methylergonovine
- Midazolam
- Nicardipine
- Nimodipine
- Nisoldipine
- Norethindrone
- Norgestrel
- Ombitasvir; Paritaprevir; Ritonavir
- Oral Contraceptives
- Oxycodone
- Pimozide
- Propafenone
- Quinidine
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Sirolimus
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sufentanil
- Tacrolimus
- Ubrogepant
- Vinorelbine
- Warfarin
