Cycloserine Brand Name– Seromycin
What is Cycloserine
Cycloserine is a second-line, broad-spectrum antibiotic used in the treatment of active pulmonary and extrapulmonary tuberculosis (TB) and urinary tract infections (UTIs).
In the treatment of TB, it is given only when other antituberculars are ineffective and in cases needing retreatment.
While cycloserine has activity against some genitourinary pathogens, it is seldom used clinically for these infections.
Cycloserine also may be used to treat Mycobacterium avium complex (MAC)† when less hazardous drugs are ineffective.
Cycloserine was approved by the FDA in 1956.
Indications
- Enterobacter sp.
- Escherichia coli
- Mycobacterium avium
- Mycobacterium bovis
- Mycobacterium intracellulare
- Mycobacterium kansasii
- Mycobacterium marinum
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- Mycobacterium ulcerans
- Staphylococcus aureus (MSSA)
- tuberculosis infection
- urinary tract infection (UTI)
Side Effects
- anxiety
- confusion
- depression
- dizziness
- drowsiness
- dysarthria
- headache
- hyperreflexia
- lethargy
- paresis
- paresthesias
- psychosis
- seizures
- tremor
- vertigo
- vitamin B6 deficiency
Monitoring Parameters
- CBC
- serum creatinine/BUN
- serum cycloserine concentrations
Contraindications
- alcoholism
- anxiety
- breast-feeding
- colitis
- depression
- diarrhea
- geriatric
- GI disease
- inflammatory bowel disease
- pregnancy
- pseudomembranous colitis
- psychosis
- renal disease
- renal failure
- renal impairment
- seizure disorder
- ulcerative colitis
Interactions
- Ethanol
- Ethionamide
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Pyridoxine, Vitamin B6
- Teriflunomide
