Copanlisib Brand Name– Aliqopa
What is Copanlisib
Copanlisib is a phosphatidylinositol-3-kinase (PI3K) inhibitor approved for the treatment of adults with relapsed follicular lymphoma who have received at least 2 prior systemic treatments.
It was granted an accelerated approval for use in these patients. Severe hyperglycemia and hypertension have been reported.
Indications
- non-Hodgkin’s lymphoma (NHL)
For the treatment of non-Hodgkin’s lymphoma (NHL)
for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies
NOTE: Copanlisib has been designated an orphan drug by the FDA for the treatment of follicular lymphoma.
Side Effects
- anemia
- anemia
- asthenia
- asthenia
- cough
- diarrhea
- diarrhea
- dysesthesia
- dyspnea
- exfoliative dermatitis
- fatigue
- fatigue
- hyperglycemia
- hyperglycemia
- hypertension
- hypertension
- hypertriglyceridemia
- hypertriglyceridemia
- hyperuricemia
- hypophosphatemia
- hypophosphatemia
- hypoxia
- infection
- infection
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- maculopapular rash
- nausea
- nausea
- neutropenia
- neutropenia
- paresthesias
- pneumonitis
- pruritus
- rash
- rash
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- vomiting
Monitoring Parameters
- blood glucose
- blood pressure
- CBC with differential
- LFTs
- pregnancy testing
Contraindications
- breast-feeding
- contraception requirements
- diabetes mellitus
- geriatric
- hepatic disease
- hyperglycemia
- hypertension
- infection
- infertility
- male-mediated teratogenicity
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- reproductive risk
- serious rash
- thrombocytopenia
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Rifampin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Tipranavir
- Tucatinib
- Voriconazole
