Conjugated Estrogens Bazedoxifene Brand Name– DUAVEE
What is Conjugated Estrogens Bazedoxifene
Conjugated estrogens bazedoxifene is the combination of natural estrogens derived from the urine of pregnant mares combined with a third generation selective estrogen receptor modulator (SERM).
The addition of the SERM to the estrogen helps prevent endometrial hyperplasia.
The combination product is used in women with an intact uterus to treat vasomotor and genitourinary symptoms of menopause and to prevent osteoporosis.
The combination was FDA approved in October 2013.
Indications
- atrophic vaginitis
- dyspareunia
- hot flashes
- menopause
- osteoporosis prophylaxis
For the treatment of moderate to severe vasomotor symptoms (i.e., hot flashes) and associated genitourinary symptoms, such as atrophic vaginitis, vulvar atrophy (kraurosis vulvae), and dyspareunia† in women with an intact uterus
Side Effects
- abdominal pain
- acne vulgaris
- acneiform rash
- alopecia
- amenorrhea
- anaphylactoid reactions
- angioedema
- anxiety
- asthenia
- biliary obstruction
- bowel ischemia
- breakthrough bleeding
- breast cancer
- breast discharge
- breast enlargement
- bronchospasm
- candidiasis
- cervicitis
- cholecystitis
- cholelithiasis
- cholestasis
- colitis
- dementia
- depression
- diarrhea
- diplopia
- dizziness
- dysmenorrhea
- dyspepsia
- edema
- elevated hepatic enzymes
- emotional lability
- endometrial cancer
- endometrial hyperplasia
- erythema multiforme
- erythema nodosum
- fatigue
- fluid retention
- galactorrhea
- gingivitis
- gynecomastia
- headache
- hepatitis
- hirsutism
- hyperglycemia
- hypertension
- hypertriglyceridemia
- impaired cognition
- insomnia
- irritability
- jaundice
- leukorrhea
- libido decrease
- libido increase
- mastalgia
- melasma
- migraine
- muscle cramps
- musculoskeletal pain
- myocardial infarction
- nausea
- new primary malignancy
- ovarian cancer
- pancreatitis
- papilledema
- paresthesias
- peliosis hepatis
- pelvic pain
- peripheral vasodilation
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- stroke
- teratogenesis
- thromboembolism
- thrombosis
- urinary incontinence
- urticaria
- vaginal bleeding
- vaginal discharge
- vaginitis
- visual impairment
- weight gain
Monitoring Parameters
- pap smear
- pelvic exam
Contraindications
- asthma
- breast cancer
- breast-feeding
- cardiac disease
- cerebrovascular disease
- cervical cancer
- children
- contact lenses
- coronary artery disease
- dementia
- depression
- diabetes mellitus
- endometrial cancer
- endometrial hyperplasia
- endometriosis
- gallbladder disease
- geriatric
- hepatic disease
- hepatocellular cancer
- hereditary angioedema
- history of angioedema
- hypercalcemia
- hypercholesterolemia
- hypertriglyceridemia
- hypocalcemia
- hypoparathyroidism
- hypothyroidism
- infants
- jaundice
- migraine
- myocardial infarction
- new primary malignancy
- obesity
- ovarian cancer
- pancreatitis
- porphyria
- pregnancy
- protein C deficiency
- protein S deficiency
- renal disease
- renal impairment
- seizure disorder
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine cancer
- uterine leiomyomata
- vaginal bleeding
- vaginal cancer
- visual disturbance
Interactions
- Acarbose
- Acetaminophen; Propoxyphene
- Albiglutide
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anastrozole
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atracurium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Azithromycin
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Bexarotene
- Bosentan
- Bromocriptine
- Budesonide
- Budesonide; Formoterol
- Calcium
- Calcium Carbonate; Magnesium Hydroxide
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Cenobamate
- Chenodiol
- Chloramphenicol
- Ciclesonide
- Cimetidine
- Cisatracurium
- Clarithromycin
- Clobazam
- Conivaptan
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Cosyntropin
- Cyclosporine
- Dalfopristin; Quinupristin
- Danazol
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Dexamethasone
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Ibuprofen
- Doxacurium
- Dulaglutide
- Duloxetine
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Exemestane
- Exenatide
- Famotidine; Ibuprofen
- Felbamate
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Griseofulvin
- Hemin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icosapent ethyl
- Imatinib
- Incretin Mimetics
- Indinavir
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lenalidomide
- Letrozole
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Liothyronine
- Liraglutide
- Lixisenatide
- Lopinavir; Ritonavir
- Lorlatinib
- Magnesium Hydroxide
- Meglitinides
- Melatonin
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methylprednisolone
- Metreleptin
- Metyrapone
- Mifepristone
- Miglitol
- Mineral Oil
- Minoxidil
- Mivacurium
- Modafinil
- Mometasone
- Nefazodone
- Nelfinavir
- Neuromuscular blockers
- Nevirapine
- Nitroprusside
- Ombitasvir; Paritaprevir; Ritonavir
- Ospemifene
- Oxcarbazepine
- Pancuronium
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prednisolone
- Prednisone
- Propoxyphene
- Raloxifene
- Rapacuronium
- Ribociclib; Letrozole
- Rifampin
- Rifamycins
- Ritonavir
- Rituximab; Hyaluronidase
- Rocuronium
- Ropinirole
- Saquinavir
- Semaglutide
- SGLT2 Inhibitors
- Somatropin, rh-GH
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Succinylcholine
- Sulfonylureas
- Tacrine
- Tazemetostat
- Testolactone
- Thiazolidinediones
- Thyroid hormones
- Tipranavir
- Topiramate
- Toremifene
- Trandolapril; Verapamil
- Tranexamic Acid
- Trastuzumab; Hyaluronidase
- Triamcinolone
- Tricyclic antidepressants
- Tubocurarine
- Ursodeoxycholic Acid, Ursodiol
- Valproic Acid, Divalproex Sodium
- Vecuronium
- Verapamil
- Warfarin
- Zafirlukast
