Conjugated Estrogens Bazedoxifene

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Conjugated Estrogens Bazedoxifene Brand Name– DUAVEE

What is Conjugated Estrogens Bazedoxifene

Conjugated estrogens bazedoxifene is the combination of natural estrogens derived from the urine of pregnant mares combined with a third generation selective estrogen receptor modulator (SERM).

The addition of the SERM to the estrogen helps prevent endometrial hyperplasia.

The combination product is used in women with an intact uterus to treat vasomotor and genitourinary symptoms of menopause and to prevent osteoporosis.

The combination was FDA approved in October 2013.

Indications

  1. atrophic vaginitis
  2. dyspareunia
  3. hot flashes
  4. menopause
  5. osteoporosis prophylaxis

For the treatment of moderate to severe vasomotor symptoms (i.e., hot flashes) and associated genitourinary symptoms, such as atrophic vaginitis, vulvar atrophy (kraurosis vulvae), and dyspareunia† in women with an intact uterus

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acneiform rash
  4. alopecia
  5. amenorrhea
  6. anaphylactoid reactions
  7. angioedema
  8. anxiety
  9. asthenia
  10. biliary obstruction
  11. bowel ischemia
  12. breakthrough bleeding
  13. breast cancer
  14. breast discharge
  15. breast enlargement
  16. bronchospasm
  17. candidiasis
  18. cervicitis
  19. cholecystitis
  20. cholelithiasis
  21. cholestasis
  22. colitis
  23. dementia
  24. depression
  25. diarrhea
  26. diplopia
  27. dizziness
  28. dysmenorrhea
  29. dyspepsia
  30. edema
  31. elevated hepatic enzymes
  32. emotional lability
  33. endometrial cancer
  34. endometrial hyperplasia
  35. erythema multiforme
  36. erythema nodosum
  37. fatigue
  38. fluid retention
  39. galactorrhea
  40. gingivitis
  41. gynecomastia
  42. headache
  43. hepatitis
  44. hirsutism
  45. hyperglycemia
  46. hypertension
  47. hypertriglyceridemia
  48. impaired cognition
  49. insomnia
  50. irritability
  51. jaundice
  52. leukorrhea
  53. libido decrease
  54. libido increase
  55. mastalgia
  56. melasma
  57. migraine
  58. muscle cramps
  59. musculoskeletal pain
  60. myocardial infarction
  61. nausea
  62. new primary malignancy
  63. ovarian cancer
  64. pancreatitis
  65. papilledema
  66. paresthesias
  67. peliosis hepatis
  68. pelvic pain
  69. peripheral vasodilation
  70. pruritus
  71. pulmonary embolism
  72. rash
  73. retinal thrombosis
  74. stroke
  75. teratogenesis
  76. thromboembolism
  77. thrombosis
  78. urinary incontinence
  79. urticaria
  80. vaginal bleeding
  81. vaginal discharge
  82. vaginitis
  83. visual impairment
  84. weight gain

Monitoring Parameters

  • pap smear
  • pelvic exam

Contraindications

  • asthma
  • breast cancer
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • cervical cancer
  • children
  • contact lenses
  • coronary artery disease
  • dementia
  • depression
  • diabetes mellitus
  • endometrial cancer
  • endometrial hyperplasia
  • endometriosis
  • gallbladder disease
  • geriatric
  • hepatic disease
  • hepatocellular cancer
  • hereditary angioedema
  • history of angioedema
  • hypercalcemia
  • hypercholesterolemia
  • hypertriglyceridemia
  • hypocalcemia
  • hypoparathyroidism
  • hypothyroidism
  • infants
  • jaundice
  • migraine
  • myocardial infarction
  • new primary malignancy
  • obesity
  • ovarian cancer
  • pancreatitis
  • porphyria
  • pregnancy
  • protein C deficiency
  • protein S deficiency
  • renal disease
  • renal impairment
  • seizure disorder
  • stroke
  • surgery
  • systemic lupus erythematosus (SLE)
  • thromboembolic disease
  • thromboembolism
  • thrombophlebitis
  • thyroid disease
  • tobacco smoking
  • uterine cancer
  • uterine leiomyomata
  • vaginal bleeding
  • vaginal cancer
  • visual disturbance

Interactions

  • Acarbose
  • Acetaminophen; Propoxyphene
  • Albiglutide
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amlodipine; Atorvastatin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Anastrozole
  • Aprepitant, Fosaprepitant
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atracurium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azithromycin
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Bromocriptine
  • Budesonide
  • Budesonide; Formoterol
  • Calcium
  • Calcium Carbonate; Magnesium Hydroxide
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbamazepine
  • Cenobamate
  • Chenodiol
  • Chloramphenicol
  • Ciclesonide
  • Cimetidine
  • Cisatracurium
  • Clarithromycin
  • Clobazam
  • Conivaptan
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Cosyntropin
  • Cyclosporine
  • Dalfopristin; Quinupristin
  • Danazol
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Daratumumab; Hyaluronidase
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Dexamethasone
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Ibuprofen
  • Doxacurium
  • Dulaglutide
  • Duloxetine
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Exemestane
  • Exenatide
  • Famotidine; Ibuprofen
  • Felbamate
  • Fludrocortisone
  • Flunisolide
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Fosphenytoin
  • Glipizide; Metformin
  • Glyburide; Metformin
  • grapefruit juice
  • Griseofulvin
  • Hemin
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Icosapent ethyl
  • Imatinib
  • Incretin Mimetics
  • Indinavir
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lenalidomide
  • Letrozole
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Liothyronine
  • Liraglutide
  • Lixisenatide
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Magnesium Hydroxide
  • Meglitinides
  • Melatonin
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methylprednisolone
  • Metreleptin
  • Metyrapone
  • Mifepristone
  • Miglitol
  • Mineral Oil
  • Minoxidil
  • Mivacurium
  • Modafinil
  • Mometasone
  • Nefazodone
  • Nelfinavir
  • Neuromuscular blockers
  • Nevirapine
  • Nitroprusside
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ospemifene
  • Oxcarbazepine
  • Pancuronium
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prednisolone
  • Prednisone
  • Propoxyphene
  • Raloxifene
  • Rapacuronium
  • Ribociclib; Letrozole
  • Rifampin
  • Rifamycins
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rocuronium
  • Ropinirole
  • Saquinavir
  • Semaglutide
  • SGLT2 Inhibitors
  • Somatropin, rh-GH
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Succinylcholine
  • Sulfonylureas
  • Tacrine
  • Tazemetostat
  • Testolactone
  • Thiazolidinediones
  • Thyroid hormones
  • Tipranavir
  • Topiramate
  • Toremifene
  • Trandolapril; Verapamil
  • Tranexamic Acid
  • Trastuzumab; Hyaluronidase
  • Triamcinolone
  • Tricyclic antidepressants
  • Tubocurarine
  • Ursodeoxycholic Acid, Ursodiol
  • Valproic Acid, Divalproex Sodium
  • Vecuronium
  • Verapamil
  • Warfarin
  • Zafirlukast

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