Clocortolone

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Clocortolone Brand Name– Cloderm

What is Clocortolone

Clocortolone pivalate is a topical, medium-potency, synthetic fluorinated corticosteroid.

It is used to relieve the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and psoriasis.

Fluorinated corticosteroids allow for treating affected areas with thicker skin such as the palms and soles.

Unlike nonfluorinated corticosteroids, clocortolone application should be avoided, if possible, on areas of thinner skin, such as the face and intertriginous areas.

Clocortolone is typically recommended for short-term use only; long-term use can lead to systemic absorption.

Indications

  1. alopecia
  2. atopic dermatitis
  3. contact dermatitis
  4. dermatitis
  5. discoid lupus erythematosus
  6. eczema
  7. exfoliative dermatitis
  8. granuloma annulare
  9. keloids
  10. lichen planus
  11. lichen simplex
  12. lichen striatus
  13. necrobiosis lipoidica diabeticorum
  14. pemphigus
  15. pityriasis rosea
  16. polymorphous light eruption
  17. pruritus
  18. psoriasis
  19. Rhus dermatitis
  20. sarcoidosis
  21. seborrheic dermatitis
  22. xerosis

Side Effects

  1. acneiform rash
  2. adrenocortical insufficiency
  3. cataracts
  4. contact dermatitis
  5. Cushing’s syndrome
  6. erythema
  7. folliculitis
  8. glycosuria
  9. growth inhibition
  10. headache
  11. hyperglycemia
  12. hypertension
  13. hypertrichosis
  14. hypothalamic-pituitary-adrenal (HPA) suppression
  15. impaired wound healing
  16. increased intracranial pressure
  17. infection
  18. maculopapular rash
  19. miliaria
  20. ocular hypertension
  21. papilledema
  22. pruritus
  23. pseudotumor cerebri
  24. purpura
  25. skin atrophy
  26. skin hypopigmentation
  27. skin irritation
  28. skin ulcer
  29. striae
  30. telangiectasia
  31. tolerance
  32. visual impairment
  33. withdrawal
  34. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acne rosacea
  • acne vulgaris
  • breast-feeding
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • geriatric
  • growth inhibition
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • infection
  • measles
  • neonates
  • occlusive dressing
  • ophthalmic administration
  • perioral dermatitis
  • pregnancy
  • skin abrasion
  • skin atrophy
  • tuberculosis
  • varicella
  • viral infection

Interactions

There are no drug interactions associated with Clocortolone products.

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