Cisplatin

Cisplatin Brand Name– Platinol | Platinol -AQ

What is Cisplatin

Cisplatin is a non-cell-cycle specific alkylating agent with activity in many different solid tumors and lymphoma.

It is indicated for the treatment of advanced testicular cancer, advanced ovarian cancer, and advanced bladder cancer, but also has several off-label uses including head and neck cancer, non-Hodgkin’s Lymphoma (NHL), small cell (SCLC) and non-small cell lung cancer (NSCLC), and many more.

Cisplatin can cause severe nephrotoxicity including acute renal failure that becomes more prolonged and severe with repeated courses of treatment.

Ensure adequate hydration before, during, and after administration; closely monitor renal function and serum electrolytes.

Indications

  1. anal cancer
  2. biliary tract cancer
  3. bladder cancer
  4. endometrial cancer
  5. gastric cancer
  6. head and neck cancer
  7. hepatocellular cancer
  8. malignant melanoma
  9. mesothelioma
  10. neuroblastoma
  11. non-Hodgkin’s lymphoma (NHL)
  12. non-small cell lung cancer (NSCLC)
  13. ovarian cancer
  14. penile cancer
  15. peripheral T-cell lymphoma (PTCL)
  16. small cell lung cancer (SCLC)
  17. testicular cancer
  18. thymic carcinoma
  19. thymoma
  20. trophoblastic disease

Side Effects

  1. alopecia
  2. anorexia
  3. asthenia
  4. azotemia
  5. blurred vision
  6. bone marrow suppression
  7. cholestasis
  8. dehydration
  9. diarrhea
  10. dysgeusia
  11. edema
  12. elevated hepatic enzymes
  13. encephalopathy
  14. erythema
  15. Fanconi syndrome
  16. fever
  17. GI perforation
  18. hearing loss
  19. heart failure
  20. hemolytic anemia
  21. hemolytic-uremic syndrome
  22. hepatic failure
  23. hiccups
  24. hyperamylasemia
  25. hyperbilirubinemia
  26. hyperuricemia
  27. hypocalcemia
  28. hypokalemia
  29. hypomagnesemia
  30. hyponatremia
  31. hypophosphatemia
  32. hypotension
  33. infection
  34. injection site reaction
  35. interstitial lung disease
  36. leukoencephalopathy
  37. leukopenia
  38. malaise
  39. muscle cramps
  40. myocardial infarction
  41. nausea
  42. nephrotoxicity
  43. neutropenia
  44. new primary malignancy
  45. optic neuritis
  46. ototoxicity
  47. pancreatitis
  48. papilledema
  49. paresthesias
  50. pericardial effusion
  51. peripheral neuropathy
  52. pneumonitis
  53. progressive multifocal leukoencephalopathy
  54. pulmonary embolism
  55. rash
  56. renal failure (unspecified)
  57. renal tubular acidosis (RTA)
  58. retinal pigment changes
  59. seizures
  60. serious hypersensitivity reactions or anaphylaxis
  61. SIADH
  62. sinus tachycardia
  63. steatosis
  64. stomatitis
  65. stroke
  66. tetany
  67. thrombocytopenia
  68. thromboembolism
  69. thrombotic microangiopathy
  70. tinnitus
  71. tissue necrosis
  72. tremor
  73. tumor lysis syndrome (TLS)
  74. visual impairment
  75. vomiting
  76. weakness
  77. wheezing

Monitoring Parameters

  • audiometry
  • CBC with differential
  • neurologic function
  • pregnancy testing
  • serum creatinine/BUN
  • serum electrolytes
  • serum magnesium

Contraindications

  • bone marrow suppression
  • breast-feeding
  • chemotherapy-induced nausea/vomiting
  • children
  • contraception requirements
  • dehydration
  • extravasation
  • fungal infection
  • geriatric
  • hearing impairment
  • herpes infection
  • infants
  • infection
  • infertility
  • intramuscular administration
  • male-mediated teratogenicity
  • neonates
  • nephrotoxicity
  • ototoxicity
  • peripheral neuropathy
  • platinum compound hypersensitivity
  • pregnancy
  • pregnancy testing
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk
  • serious hypersensitivity reactions or anaphylaxis
  • subcutaneous administration
  • varicella
  • viral infection

Interactions

  • Acyclovir
  • Adefovir
  • Amikacin
  • Aminoglycosides
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Aprotinin
  • Arsenic Trioxide
  • Bacitracin
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bleomycin
  • Bumetanide
  • Capreomycin
  • Carbamazepine
  • Cetuximab
  • Cidofovir
  • Cisapride
  • Clozapine
  • Colistimethate, Colistin, Polymyxin E
  • Cyclosporine
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Desmopressin
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Droperidol
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Entecavir
  • Ethacrynic Acid
  • Foscarnet
  • Fosphenytoin
  • Furosemide
  • Gadobenate Dimeglumine
  • Gallium
  • Gallium Ga 68 Dotatate
  • Ganciclovir
  • Gentamicin
  • Hyaluronidase, Recombinant; Immune Globulin
  • Ifosfamide
  • Immune Globulin IV, IVIG, IGIV
  • Inotersen
  • Kanamycin
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lithium
  • Live Vaccines
  • Mannitol
  • Methotrexate
  • Neomycin
  • Non-Ionic Contrast Media
  • Palifermin
  • Paromomycin
  • Penicillamine
  • Pentamidine
  • Phenytoin
  • Plazomicin
  • Polymyxin B
  • Polymyxins
  • Rituximab
  • Rituximab; Hyaluronidase
  • Streptomycin
  • Streptozocin
  • Tacrolimus
  • Telavancin
  • Telbivudine
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thalidomide
  • Tobramycin
  • Torsemide
  • Trandolapril; Verapamil
  • Tuberculin Purified Protein Derivative, PPD
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Verapamil
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