Can mexiletine be used in neuropathic pain

Can mexiletine be used in neuropathic pain

Yes. Mexiletine, an oral analogue of intravenous lidocaine, has shown some modest benefit in chronic neuropathic pain, but it still considered a second- or third-line treatment option. It is a class IB antiarrhythmic used in life-threatening ventricular arrhythmias; it should be used with caution in patients with preexisting conduction defects and is specifically contraindicated in second- and third-degree atrioventricular block.


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