Can Glucocorticoids preparations for injection be combined with an anesthetic to minimize the number of needle sticks to the patient?
Yes, anesthetic preparations can be safely mixed with GC preparations. If the GC preparation contains a paraben compound as a preservative, flocculation of the suspension is likely to occur. Immediately before injecting, shake the syringe vigorously to minimize joint precipitation. There is experimental data that anesthetics like lidocaine can be toxic to chondrocytes, so limiting the number of injections of GC with lidocaine is prudent.