Calcium Phosphate Supersaturated Brand Name– NeutraSal
What is Calcium Phosphate Supersaturated
Calcium phosphate supersaturated (NeutraSal) is a powder containing the active ingredients sodium, phosphate, calcium, chloride, and bicarbonate.
When dissolved in water, the electrolyte solution mimics natural saliva and is used in the treatment of symptoms caused by dry mouth and oral mucositis.
NeutraSal is indicated for the adjunctive treatment of discomfort associated with oral mucositis caused by radiation or high dose chemotherapy, or for hyposalivation-induced dry mouth caused by surgery, radiotherapy near the salivary glands, chemotherapy, infection or dysfunction of the salivary gland, fever, emotional factors, obstruction of the salivary ducts, or Sjogren syndrome.
It is designated by the FDA as a device and received approval in 2009.
Indications
- xerostomia
- xerostomia prophylaxis
For the treatment of xerostomia due to hyposalivation; drugs that suppress salivation (i.e., antihistamines and anticholinergic agents); surgery; chemotherapy; radiotherapy near the salivary glands; infection or dysfunction of the salivary glands; obstruction of the salivary ducts; fever; emotional factors such as fear or anxiety; or Sjogren syndrome
Side Effects
- dysgeusia
- nausea
Supersaturated calcium phosphate (NeutraSal) becomes an oral rinse after the powder is diluted in water. It is not intended for systemic use. The manufacturer states that no adverse events are anticipated if this product is accidentally swallowed.
In a randomized clinical trial (n = 58), 4 patients with head and neck cancer who had chemotherapy and/or radiation experienced a bad taste/dysgeusia and nausea with a supersaturated calcium phosphate oral rinse intended to relieve symptoms of oral mucositis.
These patients discontinued using the rinse.
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- pregnancy
- sodium restriction
Supersaturated calcium phosphate contains sodium; therefore, patients advised to adhere to sodium restriction/a low sodium diet should consult their physician before use.
Interactions
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Bisacodyl
- Bulk-forming laxative
- Burosumab
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Carbonic anhydrase inhibitors
- Chromium
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Indapamide
- Lactulose
- Loop diuretics
- Lubiprostone
- Magnesium Citrate
- Mineral Oil
- Nonsteroidal antiinflammatory drugs
- Pimozide
- Polyethylene Glycol
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Potassium-sparing diuretics
- Spironolactone
- Stool Softners
- Thiazide diuretics
- Triamterene
