Cabazitaxel

Cabazitaxel Brand Name– Jevtana

What is Cabazitaxel

Cabazitaxel is a potent microtubule stabilizer used for the treatment of metastatic hormone-refractory prostate cancer.

It is a semi-synthetic taxane prepared with a precursor extracted from yew needles.

Cabazitaxel carries a black box warning for neutropenia and hypersensitivity reactions; it is contraindicated in patients with neutrophil counts less than or equal to 1,500 cells/mm³, patients with severe hepatic impairment, and in patients with a history of severe hypersensitivity reaction to cabazitaxel or other drugs formulated with polysorbate 80.

Unlike other taxanes, cabazitaxel is a poor substrate for the multidrug resistance P-glycoprotein efflux pump and may be useful for treating multidrug-resistant tumors.

Indications

• prostate cancer

For the treatment of castration-resistant metastatic prostate cancer in patients who have previously been treated with a docetaxel-containing regimen, in combination with prednisone

Side Effects

1. abdominal pain
2. acute respiratory distress syndrome (ARDS)
3. alopecia
4. anemia
5. anorexia
6. arthralgia
7. asthenia
8. atrial fibrillation
9. atrial flutter
10. atrial tachycardia
11. AV block
12. back pain
13. bone pain
14. bradycardia
15. bronchospasm
16. constipation
17. cough
18. cystitis
19. dehydration
20. diarrhea
21. disseminated intravascular coagulation (DIC)
22. dizziness
23. dysgeusia
24. dyspepsia
25. dyspnea
26. dysuria
27. elevated hepatic enzymes
28. enterocolitis
29. erythema
30. fatigue
31. fever
32. gastritis
33. gastroesophageal reflux
34. GI bleeding
35. GI obstruction
36. GI perforation
37. headache
38. hematuria
39. hemorrhagic cystitis
40. hyperbilirubinemia
41. hypotension
42. ileus
43. infection
44. infusion-related reactions
45. leukopenia
46. nausea
47. neutropenia
48. palpitations
49. pancytopenia
50. peripheral edema
51. peripheral neuropathy
52. pneumonitis
53. pulmonary edema
54. rash
55. renal failure (unspecified)
56. serious hypersensitivity reactions or anaphylaxis
57. stomatitis
58. stroke
59. supraventricular tachycardia (SVT)
60. thrombocytopenia
61. ventricular fibrillation
62. vomiting
63. weight loss

Monitoring Parameters

• CBC with differential
• LFTs
• serum creatinine/BUN

Contraindications

• abdominal pain
• anemia
• anticoagulant therapy
• bone marrow suppression
• breast-feeding
• children
• chronic lung disease (CLD)
• constipation
• contraception requirements
• corticosteroid therapy
• dehydration
• diarrhea
• females
• geriatric
• GI bleeding
• GI perforation
• hepatic disease
• ileus
• infertility
• neutropenia
• pneumonitis
• polysorbate 80 hypersensitivity
• pregnancy
• radiation therapy
• renal failure
• reproductive risk
• respiratory distress syndrome
• sepsis
• serious hypersensitivity reactions or anaphylaxis
• taxane hypersensitivity
• thrombocytopenia
• vomiting

Interactions

• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Atazanavir
• Atazanavir; Cobicistat
• Ceritinib
• Chloramphenicol
• Clarithromycin
• Cobicistat
• Conivaptan
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Erlotinib
• Fosamprenavir
• grapefruit juice
• Idelalisib
• Indinavir
• Itraconazole
• Ketoconazole
• Letermovir
• Lopinavir; Ritonavir
• Mifepristone
• Nefazodone
• Nelfinavir
• Ombitasvir; Paritaprevir; Ritonavir
• Palifermin
• Penicillamine
• Posaconazole
• Ribociclib
• Ribociclib; Letrozole
• Ritonavir
• Saquinavir
• Telithromycin
• Tipranavir
• Tuberculin Purified Protein Derivative, PPD
• Voriconazole