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Brimonidine Brand Names
Alphagan | Alphagan P | LUMIFY | Mirvaso
What is Brimonidine
Brimonidine is a selective alpha-2 adrenergic agonist indicated for use as an ophthalmic agent to reduce intraocular pressure in patients with open-angle glaucoma and ocular hypertension, and as a topical agent to treat persistent facial erythema of rosacea.
In addition, a lower strength ophthalmic solution (0.025%) has been approved to relieve ocular redness associated with minor ocular irritation. When administered via the ophthalmic route to patients with open-angle glaucoma and ocular hypertension, brimonidine reduces intraocular pressure by approximately 2 to 6 mmHg.
Because this reduction in intraocular pressure is achieved with only minimal effect on cardiovascular or pulmonary hemodynamics, brimonidine may be a treatment option for patients in whom topical beta-blocker therapy is contraindicated.
When administered topically to patients with acne rosacea, brimonidine significantly improved facial redness as compared to vehicle control.
Side Effects
- acne vulgaris
- angioedema
- anxiety
- apnea
- asthenia
- blepharitis
- blurred vision
- bradycardia
- cataracts
- coma
- conjunctival hyperemia
- conjunctivitis
- contact dermatitis
- cough
- depression
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- epiphora
- erythema
- fatigue
- flushing
- foreign body sensation
- headache
- hypercholesterolemia
- hypertension
- hypotension
- hypothermia
- hypotonia
- infection
- influenza
- insomnia
- iritis
- keratitis
- keratoconjunctivitis
- keratopathy
- lethargy
- miosis
- musculoskeletal pain
- nasal congestion
- nasal dryness
- nausea
- ocular discharge
- ocular hemorrhage
- ocular hypertension
- ocular irritation
- ocular pain
- ocular pruritus
- orthostatic hypotension
- pallor
- palpitations
- paresthesias
- pharyngitis
- photophobia
- rash
- respiratory depression
- rhinitis
- sinus tachycardia
- sinusitis
- syncope
- urticaria
- visual impairment
- xerophthalmia
- xerostomia
Monitoring Parameters
- intraocular pressure
Contraindications
- breast-feeding
- cardiac disease
- cerebrovascular disease
- children
- contact lenses
- coronary artery disease
- depression
- hepatic disease
- infants
- neonates
- orthostatic hypotension
- pregnancy
- Raynaud’s phenomenon
- renal impairment
- scleroderma
- Sjogren’s syndrome
- thromboangiitis obliterans (Buerger’s disease)
Interactions
- Alprazolam
- Amitriptyline; Chlordiazepoxide
- Anxiolytics; Sedatives; and Hypnotics
- Barbiturates
- Benzodiazepines
- Cardiac glycosides
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Clonazepam
- Clorazepate
- Diazepam
- Estazolam
- Ethanol
- Flurazepam
- Linezolid
- Lorazepam
- Mepenzolate
- Midazolam
- Monoamine oxidase inhibitors
- Opiate Agonists
- Oxazepam
- Quazepam
- Rasagiline
- Temazepam
- Triazolam
- Tricyclic antidepressants
