Brimonidine Brinzolamide

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Brimonidine Brinzolamide Brand Name– SIMBRINZA

What is Brimonidine Brinzolamide

Brimonidine brinzolamide is available as fixed-dose ophthalmic drop that is administered as 1 drop three times daily, with the intent of reducing medication burden.

Brimonidine, a selective alpha-agonist, and brinzolamide, a carbonic anhydrase inhibitor, are combined together to decrease intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma.

The fixed dose combination resulted in a statistically significantly greater reduction in IOP (16.3—19.8 mm Hg) after 3 months of treatment than that of either brimonidine 0.2% (17.9—22.5 mm Hg; p < 0.001) or brinzolamide 1% (19.3—20.9 mm Hg; p < 0.002) administered as monotherapy in a clinical trial of 660 patients with either open-angle glaucoma or ocular hypertension.

Brimonidine brinzolamide (Simbrinza) was FDA-approved in April 2013.

Indications

  • glaucoma
  • ocular hypertension

For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Side Effects

  1. alopecia
  2. anxiety
  3. arrhythmia exacerbation
  4. asthenia
  5. blepharedema
  6. blepharitis
  7. blurred vision
  8. bradycardia
  9. chest pain (unspecified)
  10. conjunctival hyperemia
  11. conjunctivitis
  12. contact dermatitis
  13. corneal edema
  14. corneal erosion
  15. depression
  16. diarrhea
  17. diplopia
  18. dizziness
  19. drowsiness
  20. dysgeusia
  21. dyspepsia
  22. dyspnea
  23. edema
  24. erythema
  25. fatigue
  26. foreign body sensation
  27. headache
  28. hypertension
  29. hypertonia
  30. insomnia
  31. iritis
  32. keratitis
  33. keratoconjunctivitis
  34. keratopathy
  35. miosis
  36. musculoskeletal pain
  37. nasal dryness
  38. nausea
  39. ocular discharge
  40. ocular hemorrhage
  41. ocular irritation
  42. ocular pain
  43. ocular pruritus
  44. palpitations
  45. pharyngitis
  46. photophobia
  47. rhinitis
  48. sinus tachycardia
  49. syncope
  50. urticaria
  51. visual impairment
  52. xerophthalmia
  53. xerostomia

Monitoring Parameters

  • intraocular pressure

Contraindications

  • breast-feeding
  • cardiac disease
  • children
  • closed-angle glaucoma
  • contact lenses
  • depression
  • hepatic disease
  • infants
  • neonates
  • orthostatic hypotension
  • pregnancy
  • Raynaud’s phenomenon
  • renal impairment
  • sulfonamide hypersensitivity
  • thromboangiitis obliterans (Buerger’s disease)

Interactions

  • Alprazolam
  • Amitriptyline; Chlordiazepoxide
  • Anxiolytics; Sedatives; and Hypnotics
  • Barbiturates
  • Benzodiazepines
  • Cardiac glycosides
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Clonazepam
  • Clorazepate
  • Diazepam
  • Estazolam
  • Ethanol
  • Flurazepam
  • Linezolid
  • Lorazepam
  • Mepenzolate
  • Midazolam
  • Monoamine oxidase inhibitors
  • Opiate Agonists
  • Oxazepam
  • Quazepam
  • Rasagiline
  • Temazepam
  • Triazolam
  • Tricyclic antidepressants

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