Brigatinib Brand Name– Alunbrig
What is Brigatinib
Brigatinib is a tyrosine kinase inhibitor targeting multiple kinases, including anaplastic lymphoma kinase (ALK), ROS1, insulin-like growth factor-1 receptor (IGF-1R), and FLT-3, as well as EGFR deletion and point mutations.
It is FDA approved for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib.
Brigatinib has been associated with interstitial lung disease/pneumonitis, bradycardia, hypertension, visual disturbances, CPK elevations, elevated pancreatic enzymes, and hypergylcemia.
Because brigatinib can cause fetal harm and is affected by certain drug interactions, female patients of reproductive age should be advised to use nonhormonal contraception during treatment and for at least 4 months after the last dose; male patients should also use contraception during treatment and for at least 3 months after the last dose.
Indications
- non-small cell lung cancer (NSCLC)
For the treatment of non-small cell lung cancer (NSCLC)
for the treatment of locally advanced or metastatic, ALK-positive, non-small cell lung cancer (NSCLC) in patients who have not previously received an ALK inhibitor
Side Effects
- abdominal pain
- acneiform rash
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- blurred vision
- bradycardia
- cataracts
- constipation
- constipation
- cough
- diarrhea
- diplopia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- headache
- headache
- hyperamylasemia
- hyperamylasemia
- hyperglycemia
- hyperglycemia
- hypertension
- hypertension
- hypophosphatemia
- hypophosphatemia
- hypoxia
- hypoxia
- infection
- infection
- insomnia
- lymphopenia
- lymphopenia
- macular edema
- meningitis
- musculoskeletal pain
- myalgia
- myalgia
- nausea
- nausea
- paresthesias
- peripheral neuropathy
- peripheral neuropathy
- photophobia
- pneumonitis
- pneumonitis
- pulmonary embolism
- rash
- rash
- visual impairment
- visual impairment
- vomiting
- vomiting
Monitoring Parameters
- blood glucose
- creatine phosphokinase (CPK)
- pregnancy testing
- serum amylase
- serum lipase
Contraindications
- bradycardia
- breast-feeding
- cataracts
- contraception requirements
- diabetes mellitus
- hyperglycemia
- hypertension
- infertility
- myopathy
- pancreatitis
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- reproductive risk
- visual disturbance
- visual impairment
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Afatinib
- Alfentanil
- Alogliptin; Metformin
- Alpelisib
- Amiodarone
- Amlodipine; Atorvastatin
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bexarotene
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bosentan
- Bosutinib
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buspirone
- Butabarbital
- Canagliflozin; Metformin
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclosporine
- Dabigatran
- Dabrafenib
- Danazol
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Delavirdine
- Dexamethasone
- Dextromethorphan; Quinidine
- Dienogest; Estradiol valerate
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Docetaxel
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Entrectinib
- Enzalutamide
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Progesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Etravirine
- Everolimus
- Fedratinib
- Felodipine
- Fentanyl
- Fluconazole
- Fluticasone; Umeclidinium; Vilanterol
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Imatinib
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivacaftor
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lefamulin
- Letermovir
- Levonorgestrel
- Linagliptin; Metformin
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Mephobarbital
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Midazolam
- Midostaurin
- Mifepristone
- Mitotane
- Modafinil
- Morphine
- Morphine; Naltrexone
- Nafcillin
- Naldemedine
- Naloxegol
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Nisoldipine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oxycodone
- Pazopanib
- Pentobarbital
- Phenobarbital
- Phenytoin
- Pimavanserin
- Posaconazole
- Primidone
- Progesterone
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rimegepant
- Ritonavir
- Romidepsin
- Saquinavir
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Sildenafil
- Silodosin
- Simeprevir
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tacrolimus
- Talazoparib
- Telithromycin
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Tezacaftor; Ivacaftor
- Thiopental
- Ticagrelor
- Tipranavir
- Tolvaptan
- Topotecan
- Tramadol
- Trandolapril; Verapamil
- Triazolam
- Ubrogepant
- Umeclidinium
- Umeclidinium; Vilanterol
- Venetoclax
- Verapamil
- Vincristine
- Vincristine Liposomal
- Voriconazole
