Boceprevir Brand Name– VICTRELIS
What is Boceprevir
Boceprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor.
It is indicated for the treatment of genotype 1 chronic HCV infection in adults with compensated liver disease (including cirrhosis) who are treatment-naive or who have previously had no or an inadequate responded to interferon/ribavirin therapy (i.e., null responders, partial responders, relapsers).
Boceprevir must be used in combination with peginterferon alfa and ribavirin; therefore, precautions applying to peginterferon alfa and ribavirin also apply to boceprevir.
On January 21, 2015, the manufacturer released a statement informing healthcare providers of a voluntarily withdrawal of boceprevir from the US market by December 2015.
The decision to discontinue the sale and distribution of boceprevir was based on decreasing market share resulting from the development of alternative treatment options.
Indications
- hepatitis C infection
- hepatitis C virus
Side Effects
- agranulocytosis
- alopecia
- anemia
- angioedema
- arthralgia
- asthenia
- chills
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspnea
- exfoliative dermatitis
- fatigue
- infection
- insomnia
- irritability
- nausea
- neutropenia
- oral ulceration
- pancytopenia
- rash
- Stevens-Johnson syndrome
- stomatitis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vomiting
- xerosis
- xerostomia
Monitoring Parameters
- CBC with differential
- hemoglobin/hematocrit
- plasma hepatitis C RNA
- pregnancy testing
Contraindications
- agranulocytosis
- anemia
- breast-feeding
- children
- hepatic disease
- hepatitis C and HIV coinfection
- hypoalbuminemia
- infants
- male-mediated teratogenicity
- neonates
- neutropenia
- organ transplant
- pregnancy
- serious hypersensitivity reactions or anaphylaxis
- thrombocytopenia
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Ado-Trastuzumab emtansine
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bepridil
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Caffeine; Ergotamine
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cevimeline
- Chloramphenicol
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clomipramine
- Clonazepam
- Clozapine
- Cobicistat
- Cobimetinib
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Dabigatran
- Dabrafenib
- Daclatasvir
- Danazol
- Dapsone
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Desipramine
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Digoxin
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Disulfiram
- Docetaxel
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxazosin
- Doxorubicin
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Eplerenone
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Escitalopram
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etonogestrel
- Etravirine
- Ezetimibe; Simvastatin
- Felodipine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flutamide
- Fluticasone; Salmeterol
- Fluvoxamine
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Galantamine
- Glyburide
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Imatinib
- Imipramine
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivermectin
- Ixabepilone
- Ketoconazole
- Lacosamide
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Lesinurad
- Lesinurad; Allopurinol
- Leuprolide; Norethindrone
- Levomilnacipran
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Macitentan
- Maraviroc
- Mefloquine
- Meloxicam
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Methadone
- Methylergonovine
- Methylprednisolone
- Methysergide
- Midazolam
- Mifepristone
- Mirtazapine
- Mitomycin
- Mitotane
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Nafcillin
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nintedanib
- Nisoldipine
- Non-oral combination contraceptives
- Norethindrone
- Norgestrel
- Nortriptyline
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Ospemifene
- Oxybutynin
- Oxycodone
- Paclitaxel
- Panobinostat
- Paricalcitol
- Pazopanib
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Pimavanserin
- Pimozide
- Ponatinib
- Posaconazole
- Pravastatin
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Rabeprazole
- Ramelteon
- Ranolazine
- Repaglinide
- Rifabutin
- Rifampin
- Rifaximin
- Rilpivirine
- Riociguat
- Risperidone
- Ritonavir
- Rivaroxaban
- Romidepsin
- Ropivacaine
- Salmeterol
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Telithromycin
- Telotristat Ethyl
- Teniposide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Testosterone
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Tiagabine
- Ticagrelor
- Tinidazole
- Tipranavir
- Tolterodine
- Tolvaptan
- Topiramate
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Ulipristal
- Valbenazine
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Warfarin
- Yohimbine
- Zafirlukast
- Zileuton
- Ziprasidone
- Zolpidem
- Zonisamide
