Bisoprolol Hydrochlorothiazide

Bisoprolol Hydrochlorothiazide Brand Name– Ziac

What is Bisoprolol Hydrochlorothiazide

Bisoprolol hydrochlorothiazide are used together in an oral preparation to treat mild to moderate hypertension.

Hydrochlorothiazide is a thiazide diuretic. Bisoprolol is a cardioselective (beta₁-receptor specific), has low lipid solubility, and is excreted by renal and non-renal pathways.

Bisoprolol is devoid of partial agonist or membrane stabilizing activity.

The pharmacodynamic and pharmacokinetic properties of bisoprolol are similar to those of betaxolol, although betaxolol has a longer elimination half-life.

Ziac (bisoprolol hydrochlorothiazide) was approved by the FDA in March 1993.

Indications

• hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

1. abdominal pain
2. acne vulgaris
3. agranulocytosis
4. alopecia
5. angina
6. angioedema
7. anorexia
8. anxiety
9. aplastic anemia
10. arthralgia
11. asthenia
12. AV block
13. azotemia
14. back pain
15. blurred vision
16. bradycardia
17. bronchospasm
18. chest pain (unspecified)
19. colitis
20. constipation
21. cough
22. cystitis
23. depression
24. diabetes mellitus
25. diaphoresis
26. diarrhea
27. dizziness
28. drowsiness
29. dysgeusia
30. dyspepsia
31. dyspnea
32. edema
33. elevated hepatic enzymes
34. erythema multiforme
35. exfoliative dermatitis
36. fatigue
37. fever
38. flushing
39. gastritis
40. glycosuria
41. gout
42. hallucinations
43. headache
44. hearing loss
45. heart failure
46. hemolytic anemia
47. hyperbilirubinemia
48. hypercalcemia
49. hypercholesterolemia
50. hyperesthesia
51. hyperglycemia
52. hypertension
53. hypertriglyceridemia
54. hyperuricemia
55. hypochloremia
56. hypoesthesia
57. hypoglycemia
58. hypokalemia
59. hypomagnesemia
60. hyponatremia
61. hypophosphatemia
62. hypovolemia
63. impotence (erectile dysfunction)
64. insomnia
65. interstitial nephritis
66. jaundice
67. lacrimation
68. laryngospasm
69. leukopenia
70. libido decrease
71. lupus-like symptoms
72. malaise
73. memory impairment
74. metabolic alkalosis
75. muscle cramps
76. musculoskeletal pain
77. myalgia
78. myopia
79. nausea
80. nephrolithiasis
81. nightmares
82. ocular hypertension
83. ocular pain
84. orthostatic hypotension
85. otalgia
86. palpitations
87. pancreatitis
88. pancytopenia
89. paresthesias
90. peptic ulcer
91. periarteritis
92. peripheral edema
93. peripheral vasoconstriction
94. pharyngitis
95. photosensitivity
96. polyuria
97. pruritus
98. psoriasis
99. psychosis
100. purpura
101. rash
102. renal failure (unspecified)
103. restlessness
104. rhinitis
105. sialadenitis
106. sinus tachycardia
107. sinusitis
108. skin irritation
109. Stevens-Johnson syndrome
110. syncope
111. thrombocytopenia
112. tinnitus
113. toxic epidermal necrolysis
114. tremor
115. urticaria
116. vasculitis
117. vertigo
118. vomiting
119. weakness
120. weight gain
121. withdrawal
122. xanthopsia
123. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• heart rate
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• abrupt discontinuation
• acute bronchospasm
• anuria
• asthma
• AV block
• beta-blocker hypersensitivity
• bradycardia
• breast-feeding
• bronchitis
• cardiogenic shock
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• depression
• diabetes mellitus
• driving or operating machinery
• electrolyte imbalance
• emphysema
• geriatric
• gout
• heart failure
• hepatic disease
• hypercalcemia
• hypercholesterolemia
• hyperglycemia
• hyperthyroidism
• hypertriglyceridemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• infants
• metabolic alkalosis
• myasthenia gravis
• neonates
• orthostatic hypotension
• pancreatitis
• penicillin hypersensitivity
• peripheral vascular disease
• pheochromocytoma
• preeclampsia
• pregnancy
• psoriasis
• pulmonary disease
• pulmonary edema
• Raynaud’s phenomenon
• renal disease
• renal failure
• renal impairment
• sick sinus syndrome
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity
• thyroid disease
• thyrotoxicosis
• vasospastic angina
• ventricular dysfunction

Interactions

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