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Bethanechol Brand Names- Duvoid | Urecholine
What is Bethanechol
Bethanechol is a synthetic parasympathomimetic indicated for the treatment of urinary retention associated with neurogenic bladder.
Bethanechol is currently used less frequently due to the availability of more effective agents. It is an old drug which has also been used to stimulate GI motility.
However, the availability of metoclopramide and other prokinetic agents has decreased the use of bethanechol as a stimulant of GI motility.
Bethanechol occasionally is used to increase lower esophageal pressure in the treatment of gastric reflux; however, its use is limited by cholinergic side effects such as diarrhea and abdominal cramping.
Bethanechol has also been used to offset some of the bothersome anticholinergic reactions to tricyclic antidepressants.
Bethanechol has negligible cardiovascular effects at therapeutic doses.
Bethanechol was approved by the FDA in 1948.
Indications
- anticholinergic syndrome
- gastroesophageal reflux disease (GERD)
- ileus
- neurogenic bladder
- urinary retention
For treatment of acute postoperative/postpartum non-obstructive urinary retention and treatment of atonic neurogenic bladder
Side Effects
- abdominal pain
- borborygmi
- bronchospasm
- diaphoresis
- diarrhea
- dizziness
- flatulence
- flushing
- headache
- hypersalivation
- increased urinary frequency
- lacrimation
- malaise
- miosis
- nausea
- seizures
- sinus tachycardia
- syncope
- urinary urgency
- vomiting
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- bladder obstruction
- bradycardia
- breast-feeding
- children
- chronic obstructive pulmonary disease (COPD)
- coronary artery disease
- driving or operating machinery
- geriatric
- GI obstruction
- hypertension
- hyperthyroidism
- hypotension
- ileus
- inflammatory bowel disease
- intramuscular injections
- intravenous administration
- orthostatic hypotension
- parkinsonism
- peptic ulcer disease
- peritonitis
- pregnancy
- seizure disorder
- seizures
- surgery
- syncope
- urinary tract obstruction
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Alosetron
- Ambenonium Chloride
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Anticholinergics
- Articaine; Epinephrine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupropion
- Bupropion; Naltrexone
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine; Pseudoephedrine
- Cevimeline
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cholinesterase inhibitors
- Clemastine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dicyclomine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dobutamine
- Donepezil
- Donepezil; Memantine
- Dopamine
- Edrophonium
- Ephedrine
- Epinephrine
- Fexofenadine; Pseudoephedrine
- Flavoxate
- Fluoxetine; Olanzapine
- Fosfomycin
- Galantamine
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanidine
- Homatropine; Hydrocodone
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Indacaterol; Glycopyrrolate
- Isoproterenol
- Lisdexamfetamine
- Loperamide
- Loperamide; Simethicone
- Loratadine; Pseudoephedrine
- Maprotiline
- Mecamylamine
- Mepenzolate
- Meperidine; Promethazine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Methylphenidate
- Midodrine
- Naproxen; Pseudoephedrine
- Neostigmine
- Norepinephrine
- Olanzapine
- Opiate Agonists
- Oxybutynin
- Pemoline
- Phendimetrazine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Physostigmine
- Pilocarpine
- Pralidoxime
- Prilocaine; Epinephrine
- Procainamide
- Promethazine
- Propantheline
- Pseudoephedrine
- Pyridostigmine
- Quinidine
- Racepinephrine
- Ritodrine
- Rivastigmine
- Scopolamine
- Sincalide
- Sympathomimetics
- Tacrine
- Thioridazine
- Tricyclic antidepressants
- Trihexyphenidyl
- Trospium
