Bepridil

Bepridil Brand Name– Vascor

What is Bepridil

NOTE: This drug is discontinued in the U.S.

Bepridil is a calcium channel blocking agent indicated for the management of chronic stable angina pectoris.

Bepridil is unlike any other calcium channel blocker in structure, or in its overall pharmacodynamic profile. Although an effective calcium channel blocking agent, inhibiting the slow calcium channels, it also inhibits fast sodium channels, thus imparting a type I antiarrhythmic activity.

Unlike many of the other calcium channel blockers, bepridil is not an effective antihypertensive agent. Given its propensity to induce proarrhythmias, bepridil should be reserved for patients who have failed other antianginal therapies. Bepridil is associated with QT prolongation and ventricular arrhythmias including torsades de pointes.

Bepridil was approved by the FDA in December of 1990. Its patent expired in December 1995.

Indications

• angina

For the treatment of chronic stable angina (classic effort-associated angina)

Side Effects

1. abdominal pain
2. agranulocytosis
3. akathisia
4. appetite stimulation
5. asthenia
6. blurred vision
7. bradycardia
8. constipation
9. depression
10. diarrhea
11. dizziness
12. drowsiness
13. edema
14. fatigue
15. fever
16. flatulence
17. gastritis
18. gynecomastia
19. headache
20. hypotension
21. impotence (erectile dysfunction)
22. insomnia
23. libido decrease
24. myalgia
25. nausea
26. premature ventricular contractions (PVCs)
27. QT prolongation
28. sinus tachycardia
29. syncope
30. torsade de pointes
31. ventricular tachycardia
32. vertigo
33. vomiting
34. xerostomia

Monitoring Parameters

• ECG

Contraindications

• acute myocardial infarction
• AV block
• bradycardia
• breast-feeding
• bundle-branch block
• cardiogenic shock
• children
• gastroesophageal reflux disease (GERD)
• geriatric
• heart failure
• hepatic disease
• hiatal hernia
• hypokalemia
• hypotension
• myocardial infarction
• pregnancy
• QT prolongation
• renal failure
• renal impairment
• sick sinus syndrome
• torsade de pointes
• ventricular arrhythmias
• ventricular dysfunction

Interactions

• Abarelix
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• Amoxicillin; Clarithromycin; Lansoprazole
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