benefits and risks of osteoporosis medications

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Summarize the benefits and risks of pharmacologic osteoporosis medications

  • Benefits
    • Fracture reduction (significant for all FDA-approved agents).
  • Risks
    • Common side effects:
      • Upper GI symptoms: oral bisphosphonates
      • Acute-phase reactions: IV bisphosphonates (first dose)
      • Transient decrease in serum calcium: zoledronic acid, denosumab
      • Transient increase in serum and urine calcium: teriparatide, abaloparatide
    • Uncommon/Rare side effects:
      • ONJ: antiresorptive agents
      • AFF: antiresorptive agents
      • Uveitis, keratitis, optic neuritis, orbital swelling: bisphosphonates
      • Atrial fibrillation: IV bisphosphonates
      • Hypercalcemia: teriparatide, abaloparatide

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