FDA approved medications for osteoporosis

What pharmacologic agents are Food and Drug Administration (FDA)-approved, and how are they used?

MechanismRouteDoseFrequency
Antiresorptive agents
Bisphosphonates
Alendronate (Fosamax) a
Oral10 mg
70 mg
Daily
Weekly
Risedronate (Actonel) aOral5 mg
35 mg
150 mg
Daily
Weekly
Monthly
Risedronate SR (Atelvia)Oral35 mgWeekly
Ibandronate (Boniva)Oral
IV
150 mg
3 mg
Monthly
q3 Months
Zoledronic acid (Reclast)IV5 mgYearly
Nonbisphosphonates
Denosumab (Prolia)
Raloxifene (Evista)
Calcitonin (Miacalcin)
SQ
Oral
Nasal
SQ b
60 mg
60 mg
200 U
100 U
q6 Months
Daily
Daily
Daily
Estrogen therapy (multiple preparations and regimens)
Anabolic agents
Teriparatide (Forteo)
Abaloparatide (Tymlos)Romosozumab (Evenity)
SQ b
SQSQ
20 mcg
80 mcg210 mg
Daily
DailyMonthly

IV, intravenous; SQ, subcutaneously; SR, sustained release.

a Note that there is a Fosamax plus D preparation containing 70 mg of alendronate and either 2800 IU or 5600 IU of vitamin D3.

b Infusion times: IV ibandronate 1–3 minutes; IV zoledronic acid 15–30 minutes.