Azelastine Fluticasone

Azelastine Fluticasone Brand Name– Dymista

What is Azelastine Fluticasone

Azelastine fluticasone is a combination of an antihistamine and a corticosteroid administered by nasal inhalation for treating the symptoms of seasonal allergic rhinitis.

Clinical trials compared azelastine fluticasone combination therapy to monotherapy with azelastine nasal spray, monotherapy with fluticasone nasal spray, or placebo.

Combination treatment demonstrated a statistically significant greater decrease in the reflective nasal symptom score compared with the single agents alone or placebo.

Combined treatment may increase compliance in patients who require treatment with both azelastine and fluticasone. Dymista nasal spray was approved in May 2012 for adult and adolescent patients >= 12 years; in February 2015, approval was expanded to pediatric patients as young as 6 years of age.

Indications

• allergic rhinitis
• seasonal allergies

Side Effects

1. abdominal pain
2. adrenocortical insufficiency
3. anaphylactoid reactions
4. angioedema
5. anosmia
6. atrial fibrillation
7. blurred vision
8. bronchospasm
9. candidiasis
10. cataracts
11. chest pain (unspecified)
12. Churg-Strauss syndrome
13. confusion
14. conjunctivitis
15. cough
16. dental pain
17. diarrhea
18. dizziness
19. drowsiness
20. dysgeusia
21. dysosmia
22. dysphonia
23. dyspnea
24. eosinophilia
25. epistaxis
26. erythema
27. fatigue
28. fever
29. growth inhibition
30. headache
31. hoarseness
32. hypertension
33. hypothalamic-pituitary-adrenal (HPA) suppression
34. immunosuppression
35. impaired wound healing
36. infection
37. myalgia
38. nasal congestion
39. nasal dryness
40. nasal irritation
41. nasal septum perforation
42. nausea
43. ocular hypertension
44. ocular irritation
45. osteopenia
46. osteoporosis
47. palpitations
48. paresthesias
49. parosmia
50. pharyngitis
51. pruritus
52. rash
53. rhinalgia
54. rhinitis
55. rhinorrhea
56. sinus tachycardia
57. sinusitis
58. sneezing
59. throat irritation
60. tolerance
61. urinary retention
62. urticaria
63. visual impairment
64. vomiting
65. weight gain
66. wheezing
67. xerophthalmia
68. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• cataracts
• children
• corticosteroid hypersensitivity
• driving or operating machinery
• glaucoma
• growth inhibition
• hypothalamic-pituitary-adrenal (HPA) suppression
• immunosuppression
• increased intracranial pressure
• increased intraocular pressure
• infants
• infection
• nasal septal perforation
• nasal surgery
• nasal trauma
• neonates
• ocular exposure
• ophthalmic administration
• osteoporosis
• pregnancy
• tuberculosis
• varicella
• viral infection

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