Are medications to treat osteoporosis prevent fractures?
The FDA-approved medications have all been demonstrated in randomized controlled trials to significantly reduce vertebral fractures in women with postmenopausal osteoporosis. Hip fractures have also been reduced by alendronate, risedronate, zoledronic acid, and denosumab. Nonvertebral fracture reduction has been reported with alendronate, risedronate, zoledronic acid, denosumab, teriparatide, and abaloparatide. Ibandronate and raloxifene have not been shown to reduce hip or nonvertebral fractures. As discussed, there is no fracture prevention data for TRT.