Ardeparin

Ardeparin Brand Name– Normiflo

What is Ardeparin

NOTE: This drug is discontinued in the US.

Ardeparin is a low molecular weight heparin produced through partial depolymerization of porcine mucosal heparin.

Like unfractionated heparin (UFH), ardeparin is a glycosaminoglycan that consists of chains of alternating residues of D-glucosamine and iduronic acid or glucuronic acid (i.e., hexuronic acid). Although it has the same molecular subunits as unfractionated heparin (UFH), ardeparin has smaller polymer chains.

Ardeparin contains fragments of 5650—6350 daltons, while UFH contains small and large polymer chains with molecular weights between 3,000—30,000 daltons.

Ardeparin producse a more predictable anticoagulant response than UFH, reflecting their better bioavailability after subcutaneous injection, longer half-life, and dose-independent clearance.

Ardeparin is used for the prevention of DVT in patients undergoing knee replacement surgery. It was the third low-molecular weight heparin to be approved in the United States.

Final FDA approval was granted May 23, 1997.

The manufacturer, Wyeth-Ayerst, has discontinued the ardeparin product Normiflo® in the US.

Indications

  • deep venous thrombosis (DVT) prophylaxis

For the prevention of deep vein thrombosis (i.e., deep venous thrombosis (DVT) prophylaxis), which may lead to pulmonary embolism, following knee replacement surgery

Side Effects

  1. anemia
  2. arthralgia
  3. bleeding
  4. bullous rash
  5. chest pain (unspecified)
  6. confusion
  7. constipation
  8. dizziness
  9. dyspnea
  10. ecchymosis
  11. elevated hepatic enzymes
  12. epistaxis
  13. fever
  14. GI bleeding
  15. headache
  16. hematemesis
  17. hematoma
  18. hematuria
  19. hypertriglyceridemia
  20. injection site reaction
  21. insomnia
  22. intracranial bleeding
  23. maculopapular rash
  24. nausea
  25. ocular hemorrhage
  26. osteopenia
  27. osteoporosis
  28. peripheral edema
  29. petechiae
  30. pruritus
  31. retroperitoneal bleeding
  32. stroke
  33. thrombocytopenia
  34. urticaria
  35. vesicular rash
  36. vomiting

Monitoring Parameters

  • anti-Xa activity
  • hemoglobin/hematocrit
  • platelet count
  • prothrombin time (PT)
  • serum creatinine
  • stool guaiac
  • urinalysis

Contraindications

  • aneurysm
  • anticoagulant therapy
  • asthma
  • bleeding
  • breast-feeding
  • children
  • coagulopathy
  • dental disease
  • dental work
  • diabetic retinopathy
  • diverticulitis
  • endocarditis
  • epidural anesthesia
  • GI bleeding
  • hemophilia
  • heparin hypersensitivity
  • heparin-induced thrombocytopenia (HIT)
  • hepatic disease
  • hypertension
  • immune thrombocytopenic purpura (ITP)
  • inflammatory bowel disease
  • intramuscular injections
  • lumbar puncture
  • menstruation
  • paraben hypersensitivity
  • peptic ulcer disease
  • porcine protein hypersensitivity
  • pregnancy
  • renal failure
  • renal impairment
  • spinal anesthesia
  • stroke
  • sulfite hypersensitivity
  • surgery
  • thrombocytopenia
  • thrombolytic therapy
  • ulcerative colitis

Interactions

  • Antithrombin III
  • Apixaban
  • Edoxaban
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Mifepristone
  • Palifermin
  • Phentermine; Topiramate
  • Salicylates
  • Selective serotonin reuptake inhibitors
  • Sodium Hyaluronate, Hyaluronic Acid
  • Spironolactone
  • Telavancin
  • Tipranavir
  • Topiramate
  • Vorapaxar
  • Vorinostat
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top