Amlodipine and Valsartan Brand Name– Exforge
What is Amlodipine and Valsartan
Amlodipine and Valsartan (Exforge) is a combination product for treating hypertension.
The combination product is used once a patient has been titrated with individual components.
Amlodipine is a calcium-channel blocker. It is a potent vasodilator and has the longest half-life of the calcium-channel blocker group, thus allowing for once-daily dosing.
Valsartan is a specific angiotensin II antagonist which selectively and competitively blocks the AT-1 receptor, which mediates the vasopressor and aldosterone effects of angiotensin II.
Compared to losartan, valsartan has a similar efficacy and safety profile, but does not have an active metabolite or possess uricosuric effects.
Because valsartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation which is theorized to cause the cough and angioedema associated with ACE inhibitors.
However, angioedema has been rarely associated with valsartan or other angiotensin II antagonists.
Because AT-1 receptors are nearly saturated at the starting dose for most angiotensin II antagonists, the antihypertensive dose-response curve of these drugs are nonlinear, with proportionally small decreases in blood pressure attained with increased dosage.
Amlodipine and Valsartan was approved June 20, 2007.
Indications
- hypertension
Side Effects
- abdominal pain
- alopecia
- angina
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- atrial fibrillation
- azotemia
- back pain
- blurred vision
- bradycardia
- bullous rash
- carpal tunnel syndrome
- chest pain (unspecified)
- colitis
- conjunctivitis
- constipation
- cough
- depression
- diabetes mellitus
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dyspepsia
- dysphagia
- dysphonia
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- erythema
- erythema multiforme
- fatigue
- fever
- flatulence
- flushing
- gastritis
- gingival hyperplasia
- gout
- gynecomastia
- headache
- heart failure
- hematuria
- hemorrhoids
- hepatitis
- hot flashes
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypoesthesia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- leukopenia
- lymphadenopathy
- maculopapular rash
- malaise
- musculoskeletal pain
- myalgia
- nasal congestion
- nausea
- nephrolithiasis
- neutropenia
- nocturia
- orthostatic hypotension
- otalgia
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- peripheral neuropathy
- peripheral vasodilation
- pruritus
- purpura
- rash
- rhabdomyolysis
- sinus tachycardia
- sinusitis
- syncope
- teratogenesis
- thrombocytopenia
- tinnitus
- tremor
- urticaria
- vasculitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- LFTs
- serum creatinine/BUN
- serum potassium
Contraindications
- ACE-inhibitor induced angioedema
- acute myocardial infarction
- angioedema
- aortic stenosis
- Black patients
- bradycardia
- breast-feeding
- cardiogenic shock
- coronary artery disease
- dihydropyridine hypersensitivity
- geriatric
- heart failure
- hepatic disease
- hyperkalemia
- hypotension
- hypovolemia
- pregnancy
- renal artery stenosis
- renal impairment
- surgery
- ventricular dysfunction
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Angiotensin II
- Angiotensin-converting enzyme inhibitors
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Avanafil
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brexpiprazole
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine; Lidocaine
- Cabergoline
- Caffeine; Ergotamine
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clobazam
- Clofarabine
- Clopidogrel
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Danazol
- Dantrolene
- Dapagliflozin; Metformin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dofetilide
- Dorzolamide; Timolol
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Ergonovine
- Ergotamine
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esmolol
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenofibric Acid
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gemfibrozil
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- Glipizide; Metformin
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Incretin Mimetics
- Indapamide
- Indinavir
- Indomethacin
- Insulins
- Intravenous Lipid Emulsions
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lasmiditan
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levodopa
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Lomitapide
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Melatonin
- Meloxicam
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methohexital
- Methoxsalen
- Methylergonovine
- Methylphenidate
- Methysergide
- Metoprolol
- Mifepristone
- Miglitol
- Milrinone
- Mitotane
- Modafinil
- Nabumetone
- Nadolol
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nilotinib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Obeticholic Acid
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Oxaprozin
- Oxcarbazepine
- Oxycodone
- Oxymetazoline
- Paliperidone
- Pasireotide
- Pazopanib
- Penbutolol
- Pentoxifylline
- Perampanel
- Phenelzine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Piroxicam
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Posaconazole
- Potassium
- Pramlintide
- Prazosin
- Procainamide
- Procaine
- Propofol
- Propoxyphene
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinidine
- Quinine
- Rasagiline
- Remifentanil
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rofecoxib
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sincalide
- Sirolimus
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Sulindac
- Tacrolimus
- Tamsulosin
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiazolidinediones
- Thiopental
- Thiothixene
- Timolol
- Tipranavir
- Tizanidine
- Tolmetin
- Tolvaptan
- Topiramate
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamterene
- Trimethoprim
- Tucatinib
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Verapamil
- Verteporfin
- Vinorelbine
- Voriconazole
- Yohimbine
- Zafirlukast
- Ziprasidone
