Acetaminophen and Pseudoephedrine

Acetaminophen and Pseudoephedrine Brand Names

666 Cold | Allerest | Dristan Cold | Genapap Sinus | Nexafed Sinus Pressure + Pain | Ornex | Sine-Off | Sinus Relief | Sinutab | Sudafed Sinus and Cold | Sudafed Sinus Headache | Tavist | Tylenol Children’s Plus Cold | Tylenol Infants’ Cold | Tylenol Sinus | Vicks DayQuil Sinus

What is Acetaminophen and Pseudoephedrine

Acetaminophen and pseudoephedrine are used together in an oral preparation for the temporary relief of nasal congestion, sinus congestion, and/or headache pain due to allergies, common cold, hay fever, and sinusitis.

Acetaminophen is a non-narcotic, non-salicylate analgesic with similar analgesic potency to NSAIDs. Pseudoephedrine is a sympathomimetic agent commonly used to relieve nasal and sinus congestion.

Indications

1. common cold
2. headache
3. nasal congestion

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. agranulocytosis
4. anaphylactic shock
5. anaphylactoid reactions
6. angina
7. angioedema
8. anorexia
9. anxiety
10. colitis
11. contact dermatitis
12. dizziness
13. dysuria
14. edema
15. elevated hepatic enzymes
16. encephalopathy
17. erythema
18. exfoliative dermatitis
19. fever
20. hallucinations
21. headache
22. hemolysis
23. hemolytic anemia
24. hepatic necrosis
25. hypertension
26. hypoprothrombinemia
27. insomnia
28. interstitial nephritis
29. jaundice
30. maculopapular rash
31. methemoglobinemia
32. myocardial infarction
33. nausea
34. neutropenia
35. ocular hypertension
36. palpitations
37. pancytopenia
38. photophobia
39. premature ventricular contractions (PVCs)
40. pruritus
41. psychosis
42. purpura
43. rash
44. renal failure (unspecified)
45. renal papillary necrosis
46. renal tubular necrosis
47. restlessness
48. seizures
49. sinus tachycardia
50. stroke
51. thrombocytopenia
52. thrombocytosis
53. toxic epidermal necrolysis
54. urticaria
55. vomiting

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acetaminophen hypersensitivity
• acute myocardial infarction
• alcoholism
• anemia
• angina
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• coronary artery disease
• diabetes mellitus
• G6PD deficiency
• geriatric
• heart failure
• hepatic disease
• hepatitis
• hypertension
• hyperthyroidism
• immunosuppression
• infants
• infection
• MAOI therapy
• myocardial infarction
• neonates
• neutropenia
• phenylketonuria
• pregnancy
• prostatic hypertrophy
• renal disease
• renal failure
• renal impairment
• tachycardia
• urinary retention

Interactions

• Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amobarbital
• Amoxapine
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Antacids
• Aprepitant, Fosaprepitant
• Arformoterol
• Articaine; Epinephrine
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan; Chlorthalidone
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Beta-blockers
• Betaxolol
• Bethanechol
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Budesonide; Formoterol
• Bumetanide
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Bupropion
• Bupropion; Naltrexone
• Busulfan
• Butabarbital
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carteolol
• Carvedilol
• Charcoal
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Phenylephrine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cholestyramine
• Choline Salicylate; Magnesium Salicylate
• Clevidipine
• Clonidine
• Cocaine
• Codeine; Phenylephrine; Promethazine
• Colchicine
• Colchicine; Probenecid
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dapsone
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Diflunisal
• Digitoxin
• Digoxin
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Dopamine
• Dorzolamide; Timolol
• Dronabinol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Droxidopa
• Dulaglutide
• Dyphylline
• Dyphylline; Guaifenesin
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eltrombopag
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esmolol
• Ethacrynic Acid
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Exenatide
• Felodipine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Furosemide
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Phenylephrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Hydroxyprogesterone
• Iloprost
• Imatinib
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Isavuconazonium
• Isocarboxazid
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isradipine
• Labetalol
• Lamivudine, 3TC; Zidovudine, ZDV
• Lamotrigine
• Lanthanum Carbonate
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lixisenatide
• Lomitapide
• Loop diuretics
• Lopinavir; Ritonavir
• Macitentan
• Magnesium Salicylate
• Maprotiline
• Mecamylamine
• Meglitinides
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylergonovine
• Methysergide
• Metolazone
• Metoprolol
• Metyrapone
• Midodrine
• Miglitol
• Mipomersen
• Mitotane
• Moexipril
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Norepinephrine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ozanimod
• Penbutolol
• Penicillin G Benzathine; Penicillin G Procaine
• Penicillin G Procaine
• Pentobarbital
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Phenelzine
• Phenobarbital
• Phenylephrine
• Phenylephrine; Promethazine
• Pindolol
• Pioglitazone
• Pirbuterol
• Pneumococcal Vaccine, Polyvalent
• Posaconazole
• Potassium-sparing diuretics
• Pramlintide
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Procarbazine
• Propranolol
• Quinapril
• Racepinephrine
• Ramipril
• Rasagiline
• Reserpine
• Rifabutin
• Rifampin
• Riociguat
• Ritonavir
• Ropivacaine
• Rosiglitazone
• Safinamide
• Salmeterol
• Salsalate
• Secobarbital
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Selexipag
• Semaglutide
• SGLT2 Inhibitors
• Sibutramine
• Sodium Bicarbonate
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sulfinpyrazone
• Sulfonylureas
• Telaprevir
• Telotristat Ethyl
• Terbutaline
• Tetracaine
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thyroid hormones
• Timolol
• Tizanidine
• tobacco
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Treprostinil
• Tricyclic antidepressants
• Trimetrexate
• Umeclidinium; Vilanterol
• Vasodilators
• Vasopressors
• Vemurafenib
• Verapamil
• Warfarin
• Yohimbine
• Zidovudine, ZDV
• Zolmitriptan