Drugs

Which SSRI has the most anticholinergic activity? Paroxetine (Paxil) is an SSRI that, unlike the other SSRIs, can have anticholinergic effects similar to the tricyclic antidepressants (TCAs). This can result in significant cognitive impairments even at therapeutic doses. Among currently available selective serotonin reuptake inhibitors (SSRIs), paroxetine exhibits the greatest anticholinergic activity. In vitro binding …

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What are the most common side effects of SSRIs? GI side effects (e.g., nausea, loose stools) are the most common side effect of SSRIs, but these features usually resolve within the first weeks of starting treatment. What is the most common reason for discontinuation of SSRIs?  The most common reason for discontinuation of treatment with …

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Mechanisms for drug interactions among Anti Epileptics 1. Inhibition/induction of hepatic enzymes: For example, valproic acid inhibits lamotrigine metabolism, so with initiation of lamotrigine while the patient is taking valproic acid, a slower titration needs to be performed to avoid lamotrigine toxicity. Carbamazepine induces its own metabolism so levels may drop many months after being therapeutic. …

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Advantages of monotherapy for seizures 1. In most situations, one drug controls seizures as well as two or more drugs. 2. Monotherapy prevents interactions between antiepileptic medications and limits interaction with other non-AEDs. 3. Monotherapy is less expensive. 4. Monotherapy improves compliance.

Pyrithione Zinc Brand Names- CONTROLGX | DermaZinc What is Pyrithione Zinc Pyrithione zinc is a topical antiseborrheic agent. It is a cytostatic agent that reduces the turnover rate of the epidermal cells and is used to help control dandruff and seborrheic dermatitis of the body and scalp. It also exhibits antifungal and antibacterial properties. Pyrithione zinc …

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Pyrimethamine and Sulfadoxine Brand Name– Fansidar What is Pyrimethamine and Sulfadoxine Pyrimethamine and sulfadoxine are used together in an oral preparation to treat or prevent malaria, however, the combination is no longer routinely recommended for malaria prophylaxis due to the possibility of fatal toxic epidermal necrolysis (TEN). Prophylactic therapy should only be considered for travelers …

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Pyrimethamine Brand Name– Daraprim What is Pyrimethamine NOTE: Pyrimethamine is only available through a special pharmacy program, DARAPRIM Direct Program. For information on prescribing and patient enrollment, telephone 800-222-4991. Pyrimethamine is a synthetic antiparasitic agent that is chemically and pharmacologically similar to trimethoprim, a component of co-trimoxazole. Pyrimethamine, when used in combination with a sulfonamide …

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