Which SSRI has the most anticholinergic activity? What other antidepressants are anticholinergic and what problems may patients experience as a result of this effect?
Paroxetine (Paxil) is an SSRI that, unlike the other SSRIs, can have anticholinergic effects similar to the tricyclic antidepressants (TCAs). This can result in significant cognitive impairments even at therapeutic doses.
