Drugs

Do some NSAIDs inhibit COX 1 or COX 2 preferentially? Yes. A classification system is listed below according to the NSAID ability to inhibit COX-1 and/or COX-2 in therapeutic doses. Nomenclature NSAIDs in this Classification COX-1 selective Low-dose ASA (irreversibly binds to serine 530 on COX-1) COX nonselective Ibuprofen, naproxen, meclomen, indomethacin COX-2 selective Etodolac, …

Do some NSAIDs inhibit COX 1 or COX 2 preferentially Read More »

What factors affect the choice of NSAIDs? Properties of the Drug Properties of the Patient Efficacy Individual variation Tolerance Disease being treated Safety Age Convenience of dosage Other disease Formulation Other drugs Cost

What is thought to be the major mechanism of action of NSAIDs? The major mechanism of action is thought to be the inhibition of cyclooxygenase (COX), causing a decrease in PG production. There are two main isoforms of COX—COX-1 and COX-2. They are similar in size, have 60% C-DNA homology, and have similar but slightly …

Major mechanism of action of NSAIDs Read More »

Why should you know the structural classification of the NSAIDs? The drugs in each structural class tend to have similar efficacy and side effects. Therefore, if a patient fails to respond or has a side effect to a particular NSAID, it may be prudent to select an NSAID from a different structural class.

structural classification of NSAIDs I- Carboxylic acids . A) Salicylates. Acetylated—ASA a .a Available over-the-counter (non-acetylated salicylates often come in combination with other ingredients, often in tab or powder form) Nonacetylated—sodium salicylate a , magnesium salicylate a , salicylamide a , salsalate, diflunisal. B) Acetic acids. Indole derivatives—indomethacin, tolmetin, sulindac. Phenylacetic acid—diclofenac. Pyranocarboxylic acid—etodolac. C) Propionic acids—ibuprofen a , naproxen a , fenoprofen, ketoprofen, flurbiprofen, oxaprozin. D) Fenamic acids—mefenamic acid, meclofenamate sodium. E) Pyrrolizine carboxylic …

structural classification of NSAIDs Read More »

What are the beneficial effects of NSAIDs? Analgesia —some studies have shown equivalent reductions in acute pain compared with narcotics. Antipyresis —NSAIDs inhibit PGs in the central nervous system (CNS), which reduces fever. Antiinflammatory —probably achieved by a number of mechanisms (PG inhibition is the most understood and thought to represent the main mechanism of action). Antiplatelet —most NSAIDs …

Beneficial effects of NSAIDs Read More »

How often are NSAIDs used? A 2010 survey by the Centers for Disease Control estimated that 30 million adults in the United States (13% of the adult population) were regular users of NSAIDs (≥3 doses per week for at least 3 months). The number of regular NSAID users increased by over 40% compared with that …

How often are NSAIDs used Read More »