Drugs

Can Glucocorticoids preparations for injection be combined with an anesthetic to minimize the number of needle sticks to the patient? Yes, anesthetic preparations can be safely mixed with GC preparations. If the GC preparation contains a paraben compound as a preservative, flocculation of the suspension is likely to occur. Immediately before injecting, shake the syringe …

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How often can a joint or tendon sheath be injected with Glucocorticoids medications? The main concern with frequent injections is accelerated deterioration of the joint attributable to cartilage breakdown or weakening of the tendon. A single GC injection into a tendon sheath can weaken the tendon up to 40% for 3 to 12 weeks. Thus, …

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Are there any characteristics of Glucocorticoids preparations that are important to consider when determining which to use for injection therapy? Solubility of the GC preparation is an important factor when considering injection therapy. Reducing the solubility of a compound increases the duration of the local effect because diffusion of the medication will be slower. Thus, …

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Glucocorticoid Preparations Suitable for Joint or Other Injection Preparation Strengths (mg/mL) Prednisone Equivalent (mg) a Short-acting, soluble Dexamethasone sodium phosphate (Decadron, Hexadrol) 4 40 Hydrocortisone acetate (Hydrocortone) 25, 50 5, 10 Long-acting, less soluble Prednisolone tebutate (Hydeltra-TBA) 20 20 Methylprednisolone acetate (Depo-Medrol) 20, 40, 80 25, 50, 100 Dexamethasone acetate (Decadron-LA) 8 80 Longest-acting, least soluble …

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general indications for Glucocorticoids injection therapy in rheumatic conditions • Monoarthritis or disproportionate joint inflammation (after joint infection is ruled out). • Recurrent joint effusion. • Tendon sheath inflammation. • Bursitis or tendinitis refractory to NSAIDs and/or physical therapy. Note that the effectiveness of a single GC injection ranges from 50% to 100% and lasts for days to months.

What is Rayos? Rayos is the brand name of delayed-release prednisone tablets (1, 2, and 5 mg). Compared with immediate-release prednisone, it has a formulation that results in a 4-hour lag time for its release. Otherwise its mode of action and pharmacokinetics are identical to immediate-release prednisone. Rayos is administered at 10:00 p.m. and prednisone …

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What is Acthar gel? What is it used for? Acthar gel (repository corticotropin) is a purified preparation of ACTH extracted from slaughtered pigs’ pituitary glands. It is in a gel form designed to provide extended release of ACTH following injection. ACTH stimulates the adrenal cortex gland to secrete cortisol, corticosterone, and aldosterone. In addition, it …

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