Miltefosine Brand Name– IMPAVIDO What is Miltefosine Miltefosine is an alkyllysophospholipid analog, indicated for the treatment of the three main types of leishmaniasis: visceral leishmaniasis caused by Leishmania donovani; mucosal leishmaniasis caused by L. braziliensis; and cutaneous leishmaniasis caused by L. braziliensis, L. guyanensis, and L. panamensis. Leishmania is an intracellular protozoan parasite transmitted to humans via the bite of a female sandfly. …
Milrinone Brand Name– Primacor What is Milrinone Milrinone is a cardiac agent that belongs to a unique class of bipyridine inotropic/vasodilator agents. It possesses positive inotropic and vasodilatory activity, with minimal chronotropic activity. Milrinone has a shorter half-life than inamrinone and is less likely to cause thrombocytopenia. Milrinone differs in mechanism and structure from other …
Milnacipran Brand Name– Savella What is Milnacipran Milnacipran is an oral serotonin norepinephrine reuptake inhibitor (SNRI) antidepressant used for the management of fibromyalgia in the United States. Milnacipran is approved in some other countries for major depressive disorder. There is no consensus for a single medication as first-line therapy for fibromyalgia because high quality, direct …
What is Milk Thistle Silybum marianum Milk Thistle Silybum marianum also known as Carduus marianum or milk thistle, is an herb that yields a crude mixture of hepatoprotective principles designated as silymarin. While silymarin is found in the entire plant, but the highest concentration (4—6%) is found within the ripe seeds (fruit). Silymarin consists of several flavonoligans: …
Miglustat Brand Name– Zavesca What is Miglustat Miglustat is an oral therapy used for the treatment of adults with type 1 Gaucher disease. Miglustat is a competitive and reversible inhibitor of the enzyme glucosylceramide synthase, the initial enzyme responsible in the synthesis of glucosylceramide. In type 1 Gaucher disease, a genetic disease found most commonly …
Miglitol Brand Name– Glyset What is Miglitol Miglitol is an alpha-glucosidase inhibitor used for the treatment of type 2 diabetes mellitus (DM). Unlike other agents currently in this class (i.e., acarbose), miglitol is systemically absorbed prior to its activity locally in the small intestine. Like acarbose, miglitol has only modest effects on A1C levels (i.e., …
Migalastat Brand Name– Galafold What is Migalastat Migalastat is an oral alpha-galactosidase A (alpha-Gal A) pharmacological chaperone indicated for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene (GLA) variant based on in vitro assay. Fabry disease is a rare, X-linked lysosomal storage disorder caused by mutations …